The present disclosure provides a method for preventing and/or treating a damage to micro vascular integrity comprising administering to a subject, a composition comprising selected cannabinoid, thereby maintaining the microvascular integrity.

A composition and corresponding method for immunomodulation. The composition includes an emulsion formed from a pharmaceutically acceptable carrier mixed with active ingredients. The pharmaceutically acceptable carrier is between 15-85 wt % of the composition. The active ingredients include an effective amount of a hemp extract to provide a source of exogenous cannabinoids, an effective amount of a cannabinoid enhancer to inhibit cannabinoid hydrolases, an effective amount of a fatty acid amide to enhance cannabinoid activity via an entourage effect, an effective amount of a kava extract to alleviate anxiety, and an effective amount of an alkaloid to enhance bioavailability of one or more of the active ingredients.

Compositions and methods are provided for the treatment of a variety of inflammatory disease processes. The compositions generally comprise at least one edible or medicinal mushroom or extract thereof, at least one cannabinoid, at least one terpene, a curcumoinoid, and at least one flavonoid. Methods for optimizing compositions using artificial intelligence algorithms are also provided.

This disclosures relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heating material to a first temperature and a second temperature.

Compositions and methods are provided for the treatment of a variety of cancers. The compositions generally comprise at least one edible or medicinal mushroom or extract thereof, at least one cannabinoid, at least one terpene, and at least one flavonoid. Methods for optimizing compositions using artificial intelligence algorithms are also provided.

Provided herein are methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, for example, in the treatment of a mental health disorder or chronic inflammatory disease.

##STR00001##

A stick composition made of cannabidiol and/or tetrahydrocannabinol and waxes or solid-oils. The stick composition provides an effective dosage level of cannabidiol and/or tetrahydrocannabinol without unpleasant odors. The stick composition is applied topically for treating or reducing pain. In some instances, the cannabidiol and/or tetrahydrocannabinol may be the only active therapeutic agent present. The stick composition may also include one or more additives such as a vitamin, an essential oil, a flavorant, or a perfume.

Methods of treating GTC seizures by administering a THC compound are provided.

A method of opioid sparing in a subject in need of pain management is described. The method comprises administering an effective amount of a formulation consisting of tetrahydrocannabinol (THC), cannabichromene (CBC), cannabidiol (CBD) and excipients; wherein the weight % ratio of THC:CBC:CBD is 1:1:1. In one embodiment, the 1:1:1 formulation can be used in conjunction with an additional formulation containing CBC:CBD at 1:5 to 5:5 weight %, for use at certain times of day when psychoactive effects of THC are not desired. Then at other times of day, the formulation comprising THC, CBC, and CBD can be used, for example at evening or bedtime. In some embodiments, the subject is one who has previously been administered an opioid medication for pain management, and the administration of the formulation is concomitant with a reduction in the administration of the opioid medication.

The invention relates to a unique formulation for brain health. The formulation includes a mixture of CBD and THC and/or flavonoids, along with at least one antioxidant, and preferably an emulsifier, spearmint extract and a film-forming agent. The formulation improves memory and cognition as well as prevents and improves symptoms in dementia and related diseases related to deterioration or loss of memory and/or cognition.