A61K31/74

COMPOSITION CONTROLLING PHARMACOKINETICS IN THE BODY

The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.

COMPOSITION CONTROLLING PHARMACOKINETICS IN THE BODY

The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.

METHODS OF MAKING NOVEL PHARMACEUTICAL COMPOSITIONS

The present invention relates to compositions comprising complexes that are formed by polyinosinic-polycytidylic acid with a polyalkyleneimine, such as polyethyleneimine, that present uniform structural and functional features, as well as to methods for preparing the compositions that comply with regulatory requirements. The present invention additionally relates to use of said compositions as medicaments (in particular for treating cancer), alone or in combination with other therapeutic agents and/or in specific medical methods. Moreover, the administration of these compositions is associated to changes in the expression of specific genes, in cell responses, and/or in composition of immune cell populations that can be used as specific biomarkers and/or as additional target for medical treatment.

METHODS OF MAKING NOVEL PHARMACEUTICAL COMPOSITIONS

The present invention relates to compositions comprising complexes that are formed by polyinosinic-polycytidylic acid with a polyalkyleneimine, such as polyethyleneimine, that present uniform structural and functional features, as well as to methods for preparing the compositions that comply with regulatory requirements. The present invention additionally relates to use of said compositions as medicaments (in particular for treating cancer), alone or in combination with other therapeutic agents and/or in specific medical methods. Moreover, the administration of these compositions is associated to changes in the expression of specific genes, in cell responses, and/or in composition of immune cell populations that can be used as specific biomarkers and/or as additional target for medical treatment.

MOLECULAR SIEVE/FIBER COMPOSITE MATERIAL AND PREPARATION METHOD THEREOF

The disclosure provides a molecular sieve/fiber composite material comprising molecular sieves and a fiber, the molecular sieves are distributed on the fiber surface and directly contact the fiber surface; the particle diameter D90 of the molecular sieves is 0.01 to 50 m, the particle size D50 of the molecular sieves is 0.005 to 25 m; the molecular sieves are distributed uniformly on the fiber surface of the fiber. The disclosure also provides a preparation method for the molecular sieve/fiber composite material and various applications. The molecular sieve/fiber composite material has high strength, elastic recovery ability, and dimensional stability, making the composite material strong and durable. The molecular sieve/fiber composite material has a simple structure, low cost, strong stability, high repeatability of performance, and high practical efficiency, and provides the application in the fields of hemostasis, beauty, deodorization, sterilization, water purification, air purification, and radiation resistance.

MOLECULAR SIEVE/FIBER COMPOSITE MATERIAL AND PREPARATION METHOD THEREOF

The disclosure provides a molecular sieve/fiber composite material comprising molecular sieves and a fiber, the molecular sieves are distributed on the fiber surface and directly contact the fiber surface; the particle diameter D90 of the molecular sieves is 0.01 to 50 m, the particle size D50 of the molecular sieves is 0.005 to 25 m; the molecular sieves are distributed uniformly on the fiber surface of the fiber. The disclosure also provides a preparation method for the molecular sieve/fiber composite material and various applications. The molecular sieve/fiber composite material has high strength, elastic recovery ability, and dimensional stability, making the composite material strong and durable. The molecular sieve/fiber composite material has a simple structure, low cost, strong stability, high repeatability of performance, and high practical efficiency, and provides the application in the fields of hemostasis, beauty, deodorization, sterilization, water purification, air purification, and radiation resistance.

COMPOSITIONS AND METHODS FOR INVASIVE AND NON-INVASIVE PROCEDURAL SKINCARE
20210205405 · 2021-07-08 ·

Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.

COMPOSITIONS AND METHODS FOR INVASIVE AND NON-INVASIVE PROCEDURAL SKINCARE
20210205405 · 2021-07-08 ·

Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.

COMPOSITIONS AND METHODS FOR INVASIVE AND NON-INVASIVE PROCEDURAL SKINCARE
20210205405 · 2021-07-08 ·

Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.

Hydrophobic Auristatin F compounds and conjugates thereof
11857565 · 2024-01-02 · ·

Ligand Drug Conjugates of hydrophobically-modified auristatin F compounds that exhibit cytotoxic activities towards targeted cells, including abnormal cells such as cancer cells, that are MDR+ while also exhibiting bystander activities towards nearby cells having lower expression of the moeity targeted by the Conjugate.