The present invention provides: nanoparticles including a compound that includes porous silica and at least one high-atom selected from the group consisting of gadolinium atoms, iodine atoms, gold atoms, silver atoms, and platinum atoms; and a pharmaceutical composition for radiation treatment, useful for treatment of solid tumors, etc., and including these nanoparticles and a pharmaceutically acceptable carrier.

Disclosed is an edible, discontinuous gummy delivery system comprising collagen peptide particles with an average particle size from 5 to 500 μm and an average molecular weight from 1,000 to 10,000 Da dispersed in an elastic matrix, wherein the collagen peptide particles are undissolved or no more than partially dissolved in the elastic matrix, and wherein the collagen peptide particles are present in an amount from 8 to 45% of a total mass of the delivery system. Methods of preparing the gummy delivery systems are also disclosed.

Disclosed is an edible, discontinuous gummy delivery system comprising collagen peptide particles with an average particle size from 5 to 500 μm and an average molecular weight from 1,000 to 10,000 Da dispersed in an elastic matrix, wherein the collagen peptide particles are undissolved or no more than partially dissolved in the elastic matrix, and wherein the collagen peptide particles are present in an amount from 8 to 45% of a total mass of the delivery system. Methods of preparing the gummy delivery systems are also disclosed.

The present invention provides thin-film forming compositions comprising an antiseptic (e.g., povidone iodine, chlorhexidine, or octenidine), a non-aqueous solvent, and a film-forming material dissolved in the non-aqueous solvent, wherein the composition yields a continuous and flexible protective film upon substantial removal of the solvent. The compositions are useful for the treatment and prevention of infections in wounds, ulcers (e.g., decubitus ulcers and stasis ulcers), cuts, or burns, or against infections from bacterial, mycobacterial, viral, fungal, or amoeba causes, as well as for prevention of such infections in appropriate clinical settings (e.g., as liquid bandages or dressings). Additionally, the compositions of this invention are also useful for the treatment of infections and as a disinfectant skin preparation for pre- and/or post-surgical operations.

The present invention provides thin-film forming compositions comprising an antiseptic (e.g., povidone iodine, chlorhexidine, or octenidine), a non-aqueous solvent, and a film-forming material dissolved in the non-aqueous solvent, wherein the composition yields a continuous and flexible protective film upon substantial removal of the solvent. The compositions are useful for the treatment and prevention of infections in wounds, ulcers (e.g., decubitus ulcers and stasis ulcers), cuts, or burns, or against infections from bacterial, mycobacterial, viral, fungal, or amoeba causes, as well as for prevention of such infections in appropriate clinical settings (e.g., as liquid bandages or dressings). Additionally, the compositions of this invention are also useful for the treatment of infections and as a disinfectant skin preparation for pre- and/or post-surgical operations.

The present invention provides thin-film forming compositions comprising an antiseptic (e.g., povidone iodine, chlorhexidine, or octenidine), a non-aqueous solvent, and a film-forming material dissolved in the non-aqueous solvent, wherein the composition yields a continuous and flexible protective film upon substantial removal of the solvent. The compositions are useful for the treatment and prevention of infections in wounds, ulcers (e.g., decubitus ulcers and stasis ulcers), cuts, or burns, or against infections from bacterial, mycobacterial, viral, fungal, or amoeba causes, as well as for prevention of such infections in appropriate clinical settings (e.g., as liquid bandages or dressings). Additionally, the compositions of this invention are also useful for the treatment of infections and as a disinfectant skin preparation for pre- and/or post-surgical operations.

A method of performing a surgical procedure comprises inserting a medical instrument into anatomy of a patient to reach target tissue within an anatomical cavity, disinfecting anatomy within the patient with the medical instrument and performing treatment of the target tissue with the medical instrument. A medical device for providing disinfecting to a surgical site, the medical device comprises an elongate shaft extending from a proximal end to a distal end, an imaging device located proximate the distal end of the elongate shaft, a lighting element located proximate the distal end of the elongate shaft, a working channel extending at least partially through the elongate shaft and a disinfecting system attached to the elongate shaft to deliver a disinfecting capability proximate the distal end of the elongate shaft.

A method of performing a surgical procedure comprises inserting a medical instrument into anatomy of a patient to reach target tissue within an anatomical cavity, disinfecting anatomy within the patient with the medical instrument and performing treatment of the target tissue with the medical instrument. A medical device for providing disinfecting to a surgical site, the medical device comprises an elongate shaft extending from a proximal end to a distal end, an imaging device located proximate the distal end of the elongate shaft, a lighting element located proximate the distal end of the elongate shaft, a working channel extending at least partially through the elongate shaft and a disinfecting system attached to the elongate shaft to deliver a disinfecting capability proximate the distal end of the elongate shaft.

This invention relates generally to an emollient topical composition of matter that contains molecular iodine with a reduced effective vapor pressure. In specific embodiments, the composition reduces the loss of molecular iodine to the atmosphere under storage conditions after application to mammalian tissue.

This invention relates generally to an emollient topical composition of matter that contains molecular iodine with a reduced effective vapor pressure. In specific embodiments, the composition reduces the loss of molecular iodine to the atmosphere under storage conditions after application to mammalian tissue.