A nutritional composition comprises (a) one to a plurality of physiologically acceptable calcium salts and/or chelates and (b) one or more phosphorus-containing components, such as phosphate salts, and/or phosphorus-rescuing components, such as phytase. The composition is useful for phosphorus-sparing calcium supplementation of the diet of a human subject, and for treatment of a low bone density condition in a human subject in need thereof.

A nutritional composition comprises (a) one to a plurality of physiologically acceptable calcium salts and/or chelates and (b) one or more phosphorus-containing components, such as phosphate salts, and/or phosphorus-rescuing components, such as phytase. The composition is useful for phosphorus-sparing calcium supplementation of the diet of a human subject, and for treatment of a low bone density condition in a human subject in need thereof.

The present invention relates to a novel homeopathic composition useful for treating pain and/or inflammation comprising tinctures and/or diluted extracts. More particularly, there is provided a composition which contains a synergistic combination of extracts from Terminalia arjuna, Sticta pulmonaria, Colchicum autumnale, Gelsemium sempervirens, Ledum palustre and Cissus quadrangularis. The present invention also provides a method of preparation of the homeopathic drug composition as topical preparation, preferably as topical spray composition. Cissus quadrangularis extraction is also a novel process used in the composition where in cold extraction is applied for Cissus quadrangularis.

The present invention relates to a novel homeopathic composition useful for treating pain and/or inflammation comprising tinctures and/or diluted extracts. More particularly, there is provided a composition which contains a synergistic combination of extracts from Terminalia arjuna, Sticta pulmonaria, Colchicum autumnale, Gelsemium sempervirens, Ledum palustre and Cissus quadrangularis. The present invention also provides a method of preparation of the homeopathic drug composition as topical preparation, preferably as topical spray composition. Cissus quadrangularis extraction is also a novel process used in the composition where in cold extraction is applied for Cissus quadrangularis.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.

Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.

A phosphorous compound such as STMP is used as a cross-linking agent while making a starch nanoparticle with a bisphosphonate drug in an emulsion process. Negative charge of the nanoparticle is optionally reduced or reversed by adding cations and/or cationizing the starch optionally while forming the nanoparticles. Anionic active agents, such as a bisphosphonate, are optionally incorporated into the nanoparticle during the formation process. For example, a bisphosphonate salt can be added, which promotes the crosslinking reaction while also providing bisphosphonate in the nanoparticle. The retention of both calcium and bisphosphonate in the nanoparticle is improved when both salts are used. Alternatively, the nanoparticle may be used without added calcium. The nanoparticles may be useful for the treatment of osteoporosis or other skeletal disorders or cancer.

A phosphorous compound such as STMP is used as a cross-linking agent while making a starch nanoparticle with a bisphosphonate drug in an emulsion process. Negative charge of the nanoparticle is optionally reduced or reversed by adding cations and/or cationizing the starch optionally while forming the nanoparticles. Anionic active agents, such as a bisphosphonate, are optionally incorporated into the nanoparticle during the formation process. For example, a bisphosphonate salt can be added, which promotes the crosslinking reaction while also providing bisphosphonate in the nanoparticle. The retention of both calcium and bisphosphonate in the nanoparticle is improved when both salts are used. Alternatively, the nanoparticle may be used without added calcium. The nanoparticles may be useful for the treatment of osteoporosis or other skeletal disorders or cancer.