The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.

The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.

The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.

The present disclosure belongs to the field of natural high polymers and biopharmaceutical technology, and specifically relates to a Parmelia tinctorum polysaccharide XEP-70, a method of preparation, and use thereof. The sugar residues and glycosidic bonds of the polysaccharide XEP-70 provided in the present disclosure include: (1.fwdarw.4)-linked -D-GalpA, (1.fwdarw.4)-linked and (1.fwdarw.4,6)-linked -D-Glcp; (1.fwdarw.2)-linked, (1.fwdarw.6)-linked and (1.fwdarw.2,6)-linked -D-Manp; and (1.fwdarw.6)-linked and (1.fwdarw.2,6)-linked -D-Galf., with an weight-average molecular weight of 430.98 kDa. The polysaccharide may enhance cellular antioxidant capacity by activating the Nrf2-Keap1-ARE signaling pathway, effectively protecting LX-2 cells from oxidative damage induced by hydrogen peroxide.

The present disclosure belongs to the field of natural high polymers and biopharmaceutical technology, and specifically relates to a Parmelia tinctorum polysaccharide XEP-70, a method of preparation, and use thereof. The sugar residues and glycosidic bonds of the polysaccharide XEP-70 provided in the present disclosure include: (1.fwdarw.4)-linked -D-GalpA, (1.fwdarw.4)-linked and (1.fwdarw.4,6)-linked -D-Glcp; (1.fwdarw.2)-linked, (1.fwdarw.6)-linked and (1.fwdarw.2,6)-linked -D-Manp; and (1.fwdarw.6)-linked and (1.fwdarw.2,6)-linked -D-Galf., with an weight-average molecular weight of 430.98 kDa. The polysaccharide may enhance cellular antioxidant capacity by activating the Nrf2-Keap1-ARE signaling pathway, effectively protecting LX-2 cells from oxidative damage induced by hydrogen peroxide.

Provided is a composition including a dispersion medium including: an aqueous solution; a first active ingredient; a flavor agent; and a first type of polymer; and a dispersed phase including: a population of particles, each particle including: a core including: a second active ingredient a second type of polymer; and an aqueous solution; a shell, substantially surrounding the core, the shell including: a third type of polymer; a plurality of lipophilic carriers; and a third active ingredient; and a plurality of emulsifying agents.