The present disclosure relates to a use of a phloroglucinol-based compound and its salt for preventing and treating Alzheimer's disease. The pharmaceutical composition for preventing or treating Alzheimer's disease of the present disclosure fundamentally suppresses the cause of -amyloid formation, thereby exerting a remarkable effect of allowing ultimate treatment of Alzheimer's disease. The present disclosure provides the use of the single substance, which has been isolated from Dryopteris crassirhizoma and identified, for preventing or treating Alzheimer's disease for the first time.

The present invention relates to a compound of formula (I):

##STR00001##

as well as a metabolite of the compound of formula (I), pharmaceutical composition comprising the compound of formula (I) or its metabolite, and/or ophioglossum for use in the treatment, prevention and/or alleviation of symptoms of neurological complication(s) of a viral infection disease. The instant compounds, metabolites, pharmaceutical compositions and ophioglossus are particularly useful in the treatment, prevention and/or alleviation of symptoms of neurological complication(s) of a viral infection disease caused by SARS-CoV-2.

In one aspect, a composition for topical application is provided. The composition comprises a base. Dispersed within the base is elemental silver as a colloidal suspension, and plant extract from at least 6 plants. The plants are selected from the group consisting of Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, Equisetum arvense, Symphytum officinale, Panax ginseng, Rumex crispus, Arctium lappa, Trifolium pratense, Chelidonium majus, Thuja occidentalis, Urtica dioica, Mahonia aquifolium, and Galium aparine.

A combination composition including as active components, in synergistically effective amounts a huperzine of natural or synthetic origin, a pharmaceutically acceptable salt thereof or a plant extract containing huperzine, and at least two compounds selected from the group consisting of: hydroxycinnamic acids, anthoxanthins, anthocyanins and mixtures thereof.

A combination composition including as active components, in synergistically effective amounts a huperzine of natural or synthetic origin, a pharmaceutically acceptable salt thereof or a plant extract containing huperzine, and at least two compounds selected from the group consisting of: hydroxycinnamic acids, anthoxanthins, anthocyanins and mixtures thereof.

The present invention discloses a medicine for treatment or adjuvant treatment of acquired immunodeficiency syndrome, a preparation method thereof and use methods thereof. The medicine comprises: lightyellow sophora root, glabrous greenbrier rhizome, bark of Chinese corktree, raw sessile stemona root, alumen, coptis root, cortex dictamni, chinaberry bark and root-bark, pangolin scales, amber, eucommia bark, tree peony bark, clematis root, common cnidium fruit, Chinese angelica, licorice root, common macrocarpium fruit, barbary wolfberry fruit, medicinal indianmulberry root, cherokee rose fruit, chinaroot greenbier rhizome, akebia fruit, milkvetch root, Japanese climbing fern spore, asiatic pennywort herb, mulberry leaf and frankincense. The present invention not only provides the medicine capable of effectively treating the acquired immunodeficiency syndrome, but also enables the medicine to be capable of being used in conjunction with other medical technical means to easily achieve a more ideal treatment effect.

The present invention discloses a medicine for treatment or adjuvant treatment of acquired immunodeficiency syndrome, a preparation method thereof and use methods thereof. The medicine comprises: lightyellow sophora root, glabrous greenbrier rhizome, bark of Chinese corktree, raw sessile stemona root, alumen, coptis root, cortex dictamni, chinaberry bark and root-bark, pangolin scales, amber, eucommia bark, tree peony bark, clematis root, common cnidium fruit, Chinese angelica, licorice root, common macrocarpium fruit, barbary wolfberry fruit, medicinal indianmulberry root, cherokee rose fruit, chinaroot greenbier rhizome, akebia fruit, milkvetch root, Japanese climbing fern spore, asiatic pennywort herb, mulberry leaf and frankincense. The present invention not only provides the medicine capable of effectively treating the acquired immunodeficiency syndrome, but also enables the medicine to be capable of being used in conjunction with other medical technical means to easily achieve a more ideal treatment effect.

The present invention relates to a process for obtaining a juice of fresh plants, characterized in that said fresh plants, with the exclusion of the seeds only, are subjected to a thermomechanical treatment consisting in extruding the fresh plants in an extruder, combined with a heat treatment which makes it possible to inactivate the endogenous enzymes and to preserve the molecules of compounds of interest in the native form thereof, in the absence of solvent, followed by a juice recovery operation.

The present invention relates to a process for obtaining a juice of fresh plants, characterized in that said fresh plants, with the exclusion of the seeds only, are subjected to a thermomechanical treatment consisting in extruding the fresh plants in an extruder, combined with a heat treatment which makes it possible to inactivate the endogenous enzymes and to preserve the molecules of compounds of interest in the native form thereof, in the absence of solvent, followed by a juice recovery operation.

A eutectic extraction solvent for extracting plant (e.g. vegetable) and/or animal and/or prokaryotic biological material, wherein the solvent is a clear, stable and fluid mixture comprising: (a) betaine or a hydrated form of betaine; (b) at least one hydrogen bond donor compound selected from the group consisting of polyols and organic acids; and (c) water with the proviso that the eutectic extraction solvent does not contain any exogenous sugar and/or amine salt and/or anion.