The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsFree-B-Ring flavonoids and flavansfor use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsFree-B-ring flavonoids and flavansfor use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

The invention relates to a method for producing a fermented mineral pill with constipation reduction and fatigue recovery, the method comprising: cultivating Bacillus subtilis using a rice straw; fermenting at least one of a rice-husk powder, a rice-bran powder and a lentil bean power using the Bacillus subtilis to acquire a fermented mixture; and shaping and drying the fermented mixture into solid pills.

The invention relates to a method for producing a fermented mineral pill with constipation reduction and fatigue recovery, the method comprising: cultivating Bacillus subtilis using a rice straw; fermenting at least one of a rice-husk powder, a rice-bran powder and a lentil bean power using the Bacillus subtilis to acquire a fermented mixture; and shaping and drying the fermented mixture into solid pills.

The invention relates to a method for producing a fermented mineral pill with constipation reduction and fatigue recovery, the method comprising: cultivating Bacillus subtilis using a rice straw; fermenting at least one of a rice-husk powder, a rice-bran powder and a lentil bean power using the Bacillus subtilis to acquire a fermented mixture; and shaping and drying the fermented mixture into solid pills.

The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.

The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.

A method for producing a plant-based extract composition having the effect of enhancing nutrition and immunity comprises the following steps: (i) preparing materials; (ii) creating a base mixture; (iii) creating a foundation mixture; (iv) creating a first temporary mixture; (v) creating a second temporary mixture; (vi) creating a uniform mixture; (vii) creating a post-incubation mixture; and (viii) concentrating the post-incubation to obtain the plant-based extract composition having the effect of enhancing nutrition and immunity. This composition includes the following components: Ngoc Linh ginseng (Panax vietnamensis) extract; jiaogulan (Gynostemma pentaphyllum) powder; maingay's tree (Cratoxylum maingayi) powder; nodding clubmoss (Lycopodiella cernua) powder; red ginseng (Radix Ginseng Rubra) powder; codonopsis root (Codonopsis pilosula) powder; angelica root (Angelica sinensis) powder; rice bran oil, legume powder; coenzyme Q10; ginsenoside Rb1 extract; and honey.

A method for producing a plant-based extract composition having the effect of enhancing nutrition and immunity comprises the following steps: (i) preparing materials; (ii) creating a base mixture; (iii) creating a foundation mixture; (iv) creating a first temporary mixture; (v) creating a second temporary mixture; (vi) creating a uniform mixture; (vii) creating a post-incubation mixture; and (viii) concentrating the post-incubation to obtain the plant-based extract composition having the effect of enhancing nutrition and immunity. This composition includes the following components: Ngoc Linh ginseng (Panax vietnamensis) extract; jiaogulan (Gynostemma pentaphyllum) powder; maingay's tree (Cratoxylum maingayi) powder; nodding clubmoss (Lycopodiella cernua) powder; red ginseng (Radix Ginseng Rubra) powder; codonopsis root (Codonopsis pilosula) powder; angelica root (Angelica sinensis) powder; rice bran oil, legume powder; coenzyme Q10; ginsenoside Rb1 extract; and honey.

Disclosed is a pharmaceutical composition for treating presbyopia including a cholinesterase inhibitor in a therapeutically effective amount for treating presbyopia. Additionally, the pharmaceutical composition further includes an acetylcholinesterase inhibitor in a therapeutically effective amount for treating presbyopia. A method for treating presbyopia is also disclosed, including the following steps: administering a pharmaceutical composition including a cholinesterase inhibitor or a combination of a cholinesterase inhibitor and an acetylcholinesterase inhibitor to a patient in need thereof; and simultaneously detecting changes in reading distance (UNVA40) and computer screen usage distance (UNVA66) of the patient.