Provided herein are tumor-antigen VCX/Y specific peptides and engineered VCX/Y specific T cell receptors. Also provided herein are methods of generating VCX/Y-specific immune cells and their use for the treatment of cancer. In addition, the VCX/Y-specific peptides may be used as a vaccine.

This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 m, but less than 250 m; an apparent specific volume of 2 to less than 15 cm.sup.3/g; and an organic carbon content from residual impurities, which is defined by the total organic carbon content (%) during 1% NaOH extraction to the total organic carbon content (%) during pure water extraction, of over 0.07 to 0.3%.

This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 m, but less than 250 m; an apparent specific volume of 2 to less than 15 cm.sup.3/g; and an organic carbon content from residual impurities, which is defined by the total organic carbon content (%) during 1% NaOH extraction to the total organic carbon content (%) during pure water extraction, of over 0.07 to 0.3%.

A traditional Chinese medicine composition for treating hand-foot syndrome after targeted drug treatment is mainly prepared from the following components by weight: 20-50 parts of Radix Sophorae Flavescentis, 20-50 parts of Herba Taraxaci, 20-50 parts of Flos Chrysanthemi Indici, and 20-50 parts of Herba Cum Radice Violae Yedoensitis, 20-50 parts of Rhizoma Smilacis Glabrae, 30-60 parts of Radix Astragali Seu Hedysari, 10-35 parts of Kochia scoparia (L.) Schrad, 10-45 parts of Carthamus tinctorius L., 15-45 parts of Cortex Radicis Dictamni Dasycarpi, 5-15 parts of Herba Ephedrae, 5-25 parts of Angelica sinensis, 5-25 parts of Rhizoma Ligustici Chuangxiong, 10-30 parts of Radix Rehmanniae, 5-15 parts of Ramulus cinnamomi, 10-30 parts of Cynanchum otophyllum Schneid, 5-15 parts of Semen Sinapis Albae, 5-20 parts of Arisaema heterophyllum Blume, 5-20 parts of Typhonium blumei Nicolson & Sivadasan, and 10-40 parts of Radix Glycyrrhizae.

A traditional Chinese medicine composition for treating hand-foot syndrome after targeted drug treatment is mainly prepared from the following components by weight: 20-50 parts of Radix Sophorae Flavescentis, 20-50 parts of Herba Taraxaci, 20-50 parts of Flos Chrysanthemi Indici, and 20-50 parts of Herba Cum Radice Violae Yedoensitis, 20-50 parts of Rhizoma Smilacis Glabrae, 30-60 parts of Radix Astragali Seu Hedysari, 10-35 parts of Kochia scoparia (L.) Schrad, 10-45 parts of Carthamus tinctorius L., 15-45 parts of Cortex Radicis Dictamni Dasycarpi, 5-15 parts of Herba Ephedrae, 5-25 parts of Angelica sinensis, 5-25 parts of Rhizoma Ligustici Chuangxiong, 10-30 parts of Radix Rehmanniae, 5-15 parts of Ramulus cinnamomi, 10-30 parts of Cynanchum otophyllum Schneid, 5-15 parts of Semen Sinapis Albae, 5-20 parts of Arisaema heterophyllum Blume, 5-20 parts of Typhonium blumei Nicolson & Sivadasan, and 10-40 parts of Radix Glycyrrhizae.

A therapeutic method of treatment of diabetes mellitus, particularly diabetes which acquires insulin resistance, including administering a therapeutically effective amount of Chinese herbal medicine to a subject in need. The Chinese herbal medicine is the decocting extract including the mixture of raw oyster shell powder, raw Os Draconis, Haematitum (Hematite), Magnetitum (Magnetite), radix Achyranthis Bidentatae (Achyranthes bidentata), rhizoma Dioscoreae (Dioscoreae Rhizoma), radix Paeoniae Rubra (Paeoniae Radix Rubra), radix Rehmanniae (Rehmannia), and semen Platycladi (Platycladi Semen).

A therapeutic method of treatment of diabetes mellitus, particularly diabetes which acquires insulin resistance, including administering a therapeutically effective amount of Chinese herbal medicine to a subject in need. The Chinese herbal medicine is the decocting extract including the mixture of raw oyster shell powder, raw Os Draconis, Haematitum (Hematite), Magnetitum (Magnetite), radix Achyranthis Bidentatae (Achyranthes bidentata), rhizoma Dioscoreae (Dioscoreae Rhizoma), radix Paeoniae Rubra (Paeoniae Radix Rubra), radix Rehmanniae (Rehmannia), and semen Platycladi (Platycladi Semen).

The present invention is directed to a therapeutic method of treatment of diabetes mellitus, particularly diabetes which acquires multiple drug resistance, comprising administering a therapeutically effective amount of Chinese herbal medicine to a subject in need. The Chinese herbal medicine is the decocting extract including the mixture of raw oyster shell powder, raw Os Draconis, Haematitum, Magnetitum, radix Achyranthis Bidentatae, rhizoma Dioscoreae, radix Paeoniae Rubra, radix Rehmanniae, and semen Platycladi.

The present invention is directed to a therapeutic method of treatment of diabetes mellitus, particularly diabetes which acquires multiple drug resistance, comprising administering a therapeutically effective amount of Chinese herbal medicine to a subject in need. The Chinese herbal medicine is the decocting extract including the mixture of raw oyster shell powder, raw Os Draconis, Haematitum, Magnetitum, radix Achyranthis Bidentatae, rhizoma Dioscoreae, radix Paeoniae Rubra, radix Rehmanniae, and semen Platycladi.

The present invention is directed to a method for treating malignant pleural effusion comprising administering a first herbal medicine composition to a subject in need; wherein the first chinese herbal medicine is an extract of a first mixture comprising Poria, Grifola, Rhizoma Atractylodis, Rhizoma Alismatis, Semen Lepidii, Rhizoma Atractylodis Macrocephalae, Herba Ephedrae, Fructus Jujubae, Fructus Crataegi, dried Langan, Radix Stephaniae Tetrandrae, and Rhizoma Gastrodiae; Ginseng powder; and a second mixture comprising Radix Kansui, Euphorbia pekinensis, Flos Genkwa.