This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.

The invention pertains to the use of a probiotic and a beta-lactoglobulin-derived peptide in the manufacture of a product for use in inducing oral tolerance, and/or treatment, prevention or reducing the risk of allergy in a subject, in particular cow's milk protein allergy.

Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as cognitive disorders. The methods relate to a regimen of pulsed dosing of blood plasma or blood plasma fractions.

A multi-efficacy traditional Chinese medicine compound composition and application thereof in pharmaceutical preparations are disclosed. The traditional Chinese medicine extracts are combined with the glucosamine, the collagen and the chondroitin sulfate, so that the multi-efficacy traditional Chinese medicine compound composition is prepared. The traditional Chinese medicine compound composition starts from improving the health of bone and joint and accompanying cardiovascular disease, selects the medicinal materials, and optimizes the extraction process of the traditional Chinese medicine for the diseases dominated by degenerative osteoarthritis. The disclosure has the efficacious of improving the symptoms of degenerative osteoarthritis, reducing blood pressure, improving the symptoms with osteoporosis, improving the symptoms with cardiovascular disease, improving the symptoms with urinary system disease, etc. It also has the characteristics of less dosage, significant curative effect and various functions, which is suitable for market promotion and application.

The present disclosure relates to the method for the production of iodinated proteins to be used as biologically active substances and can be used for preventing and treating of the iodine deficiency conditions in humans and animals, in particular, when producing food products, biologically active food supplements, medicinal agents and veterinary preparations and foodstuffs. To this end, a method for the production of iodinated proteins and/or their hydrolyzates is proposed, comprising fermentation of the source protein raw material with an inorganic iodine aqueous solution by introducing therein a buffer mixture of reagents with a reaction mixture of enzymes immobilized on semipermeable membranes or on inert supports. The invention provides for the production of proteins with a determinated iodinated tyrosine amino acid residues content.

The present disclosure provides screening methods for identifying a sterile α and HEAT/armadillo motif-containing protein-1 (SARM1) NADase modulator, specifically, inhibitor, using at least one full length or near full length catalytically active SARM1 or any fragment or variant thereof. The present disclosure further provides SARM inhibitors identified by the screening methods, and therapeutic compositions and methods for treating, conditions or disorders associated directly or indirectly with axonal and/or cellular degradation.

Compositions comprising a manganese mineral are provided. In specific embodiments, the manganese mineral contains manganese carbonate (MnCO.sub.3), which may be in the form of rhodochrosite. The compositions may be administered topically to a subject, or in some versions by inhalation. For example, the compositions may be administered by direct contact with the subject's skin or by inhalation through the subject's nasal passages or mouth. Such application of the disclosed compositions may increase the subject's collagen synthesis, prolidase activity (an enzyme responsible for collagen function), and manganese superoxide dismutase activity (an antioxidant having manganese in its active site) in the subject.

The present invention relates to compositions and methods for preventing or treating skeletal muscle conditions or diseases. The present invention also relates to compositions and methods that help to increase levels of NAD+ in skeletal muscle. Preferably, the present invention relates to compositions and methods that use trigonelline, high protein and/or creatine and/or tryptophan for preventing or treating skeletal muscle conditions or diseases. The recipient of the compositions or methods of the invention can be, for example, an elderly individual or an individual with sarcopenia or an individual in need of the compositions and methods of the invention for recovery of skeletal muscles, for example, after exercise, muscle injury or surgery.

The present disclosure relates to human milk compositions and methods of making and using the same. In particular, the disclosure features methods of using human milk compositions to feed subjects before and/or after surgery or medical operations and that are useful in promoting recovery.

The present application relates to nutritional compositions comprising lactic acid-producing bacteria.