Peptides that generate an immune response to glioma-related H3.3 proteins and methods of their use are provided.

The invention relates to organic and bio-organic combinatorial chemistry, specifically to new combinatorial libraries of oligopeptide derivatives and supra molecular structures based thereon that have powerful antiviral properties when used without being separated into individual components. The aim of the invention is to synthesize combinatorial oligopeptide derivatives that have antiviral properties and a new mechanism of action and that can be used to significantly improve treatment effectiveness and reduce treatment duration in the case of viral diseases such as influenza and herpesvirus infections. This aim is achieved by synthesizing combinatorial oligopeptide derivatives having antiviral properties, characterized in that the combinatorial oligopeptide derivatives, in the structure of which lysine, histidine, and arginine amino groups as well as serine and threonine alcoholic residues are available for modification, are simultaneously combinatorially modified by at least two different covalent modifiers, and subsequently the resulting combinatorial mixture is used whole, without purification and without separation of each individual derivative, as an antiviral agent in various pharmaceutical compositions. The result is modified complementary protected oligopeptides that have powerful antiviral properties and on the basis of which a medicinal, veterinary, or cosmetic product having a broad spectrum of activity can be obtained. The agent has a broad spectrum of action and low toxicity, and is suitable for industrial production.

The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by PKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of PKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of PKC on ALMS1.

The present invention relates to the identification of ALMS1 as the missing player involved in the regulation of the insulin-mediated glucose uptake through GLUT4 sorting vesicles, and to the down-regulation of ALMS1 by PKC. Accordingly, the present invention relates to a molecule capable of preventing the binding of PKC on ALMS1 for use for treating or preventing diabetes, in particular type 2 diabetes. In addition, the present invention relates to a method for identifying molecule capable of preventing the binding of PKC on ALMS1.

The invention provides a food supplement comprising chromium and the five amino acids leucine, isoleucine, valine, threonine and lysine, wherein leucine, isoleucine, valine, threonine and lysine are the only amino acids present in the food supple ment, and wherein the sum content of the five amino acids is from 1.75 to 3.5 g per dose of the food supplement, and wherein the content of chromium is from 4.5 to 61 g per dose of the food supplement. A food composition comprising the food supplement, as well as the five amino acids for use in a method of treating, controlling or preventing diseases or conditions related to the metabolic syndrome, treating or controlling diabetes, treating, controlling or preventing obesity, promoting satiety, promoting weight loss, or promoting maintenance of a healthy bodyweight, by lowering postprandial glycaemia, and preferably also by lowering postprandial insulin secretion, are also provided.

The invention provides a food supplement comprising chromium and the five amino acids leucine, isoleucine, valine, threonine and lysine, wherein leucine, isoleucine, valine, threonine and lysine are the only amino acids present in the food supple ment, and wherein the sum content of the five amino acids is from 1.75 to 3.5 g per dose of the food supplement, and wherein the content of chromium is from 4.5 to 61 g per dose of the food supplement. A food composition comprising the food supplement, as well as the five amino acids for use in a method of treating, controlling or preventing diseases or conditions related to the metabolic syndrome, treating or controlling diabetes, treating, controlling or preventing obesity, promoting satiety, promoting weight loss, or promoting maintenance of a healthy bodyweight, by lowering postprandial glycaemia, and preferably also by lowering postprandial insulin secretion, are also provided.

This invention discloses methods and compositions for the treatment of demyelinating disorders. Specifically, the invention relates to the use guanabenz or guanabenz derivative for treating demyelinating disorders.

This invention discloses methods and compositions for the treatment of demyelinating disorders. Specifically, the invention relates to the use guanabenz or guanabenz derivative for treating demyelinating disorders.

The present invention relates to improved pharmaceutical formulations, uses and methods for the oral delivery of peptide drugs with advantageously high bioavailability, safety and costeffectiveness. In particular, the invention provides a peptide drug having a molecular weight of equal to or less than 5 kDa for use as a medicament, wherein said peptide drug is to be administered orally in combination with a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex and/or a pharmaceutically acceptable iron salt/complex, and with a pharmaceutically acceptable complexing agent. The invention also provides a pharmaceutical composition comprising: a peptide drug having a molecular weight of equal to or less than 5 kDa; a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex and/or a pharmaceutically acceptable iron salt/complex; and a pharmaceutically acceptable complexing agent.

The present invention relates to improved pharmaceutical formulations, uses and methods for the oral delivery of peptide drugs with advantageously high bioavailability, safety and costeffectiveness. In particular, the invention provides a peptide drug having a molecular weight of equal to or less than 5 kDa for use as a medicament, wherein said peptide drug is to be administered orally in combination with a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex and/or a pharmaceutically acceptable iron salt/complex, and with a pharmaceutically acceptable complexing agent. The invention also provides a pharmaceutical composition comprising: a peptide drug having a molecular weight of equal to or less than 5 kDa; a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex and/or a pharmaceutically acceptable iron salt/complex; and a pharmaceutically acceptable complexing agent.