Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.

The invention relates to an injectable composition for rapid and sustained delivery of a biologically active agent and to uses of the injectable composition in the treatment or prevention of a condition in a subject. The injectable composition comprises a water-in-oil emulsion having an aqueous phase dispersed in an oil phase. The aqueous phase comprises a plurality of hydrogel particles and an aqueous liquid and a biologically active agent is contained in the hydrogel particles and in the aqueous liquid.

Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans, wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.

The invention relates to antigenic polypeptides derived from a naturally occurring R. microplus protein, and nucleic acids encoding such polypeptides. The polypeptides elicit an immune response which, in turn, produces detrimental effects in R. microplus feeding on vaccinated cattle. Thus, the present disclosure provides novel vaccines to protect cattle from R. microplus infestation.

The present invention describes vaccine compositions for treatment and/or prevention against sea lice infestation in salmon. The present invention further describes nucleic acids, host cells, vectors and methods of using said vaccine for the prevention and/or treatment of sea lice infestation in salmon.

Provided are compositions and methods used for combating ticks and transmission of tick-borne pathogens to tick hosts. The compositions include tick mouthpart protein antigens. The method of using the compositions results in decreased tick persistence time, decreased tick feeding, and decreased tick-borne pathogen transmission from tick to the host.

Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans, wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.

The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

The present invention is a multivalent vaccine for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent vaccine are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy.

Disclosed are transmission blocking vaccines for prevention or spread of one or more flaviviruses, and in particular, for prevention or spread of dengue virus. Vaccines can incorporate a polypeptide or a recombinant virus encoding a polypeptide that is non-homologous to human proteins and that is involved in flavivirus infection in a mosquito. Vaccines can include multiple components for multi-level attack against mosquito-borne diseases including flaviviruses and malaria.