There is discussed nematode antigens capable of causing an immune response in a host such that a protective effect is provided to the host in relation to the nematode. Antigens, compositions for the treatment of parasitic nematode infections, methods of prophylaxis and treatment of parasitic nematode infections, and vaccines to reduce and/or control parasitic nematode infections are provided.

A hybridoma cell stain and a monoclonal antibody secreted therefrom and application thereof belong to the technical field of prevention and treatment of Trichinella spiralis (T. spiralis). Aiming at the technical problem of how to specifically diagnose trichinellosis, the disclosure provides a hybridoma cell strain deposited under an accession number of CGMCC No. 18317. Tests show that the monoclonal antibody Ts-ZH68-2A4-Ab secreted by the hybridoma cell strain can compete with the positive serum of pigs infected with T. spiralis for binding to Ts-ZH68 antigen, and the recognition peptide is .sup.222GVDRSATCQGDSGGP.sup.236. The monoclonal antibody of the disclosure and the Ts-ZH68 protein B cell epitope polypeptide recognized by the monoclonal antibody can be used to prepare a reagent or a vaccine for diagnosing or preventing infection of T. spiralis, laying the foundation for establishment of a serological diagnosis method of T. spiralis.

Antigenic polypeptides derived from a naturally occurring horn fly protein, and nucleic acid molecules encoding the polypeptides, are described. The polypeptides elicit an immune response which, in turn, produces detrimental effects in horn flies feeding on vaccinated cattle. Thus, the present disclosure provides a novel horn fly vaccine.

Isolated proteins from caligid copepods, mutant protein from caligid copepods, polynucleotides encoding the same, and antigens and vaccines comprising the same, in particular for the treatment or prevention of caligid copepod infection in fish. Proteins are a mutant of fructose bisphosphate aldolase (FBP), a mutant of glutathione 5-transferase 1, isoform D (GST), peptidyl prolyl cis-trans isomerase 5-precursor (PPIase), glutathione S-transferase 1, isoform D (GST), a mutant of triosephosphate isomerase (TIM) and cystathionine gamma-lyase (CSE).

A composition inhibits respiratory viruses and a method prevents and treats a respiratory. Respiratory viral infections are extremely common clinically, but the current therapeutic drugs for viral infections still cannot meet the treatment needs. An inhalant inhibits respiratory viruses and adopts a method of inhaling high-temperature acetic acid steam for prevention and treatment. Acetic acid in the high-temperature steam can release hydrogen ions to inactivate viruses in the respiratory tract, so as to prevent the onset of the disease and provide a therapeutic effect. In addition, the composition can be used to inhibit fungi and bacteria in vitro and prevent skin diseases and respiratory diseases caused by bacteria and fungi. The prevention and treatment method is easy to implement and has low costs and important clinical application value.

The present invention provides methods and compositions for immunizing a subject against malaria.

Described herein are combinations of the antibacterial peptide monomers, and analogs, derivatives thereof, with antibiotics. The invention further relates to methods for using the combination to increase the sensitivity of antibiotic resistant bacteria to an antibiotic, widen the therapeutic index of the antibacterial peptide, and treat bacterial infections in a host animal.

The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

The present invention relates to cell-free larval preparations of Heligmosomoides polygyrus bakeri (Hpb) helminths, wherein said larval preparation is obtainable from cells of the L3-developmental stage larva of said Hpb helminths, wherein said larval preparation is capable of modulating the innate mammalian immune system as well as methods of making and uses thereof.

This invention relates to novel fusion peptides and immunogenic compositions containing the fusion peptides useful in the control and prevention of tick infestations. The invention also relates to compositions comprising said fusion peptides, methods of vaccination against tick infestation using said fusion peptides and compositions, and kits for use with such compositions and methods.