The invention relates to tau, to antibodies and related fragments thereof for binding to tau, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, including tauopathies. The invention also relates to compositions comprising tau antibodies for binding to tau and their use in combination with acoustic energy.

It discloses a proteolysis targeting chimeric molecule, a preparation method and an application thereof. The proteolysis targeting chimeric molecule provided by the disclosure can inhibit the expression of BCR-ABL and/or CRBN protein in BCR-ABL and/or CRBN positive leukemia K562 cells to varying degrees, and thus can be used to prepare drugs for treating BCR-ABL and/or CRBN positive leukemia, wherein the proteolysis targeting chimeric molecule with n=3 has excellent photo-isomerization activity, and can be used in preparation of the reagents or drugs for light-regulated degradation of BCR-ABL and/or CRBN protein. The disclosure also provides a method for synthesizing the series of proteolysis targeting chimeric molecules.

A system includes a control device and a magnetic device coupled to the control device. The magnetic device is configured to inductively couple to a treatment target including one or more cells exposed to an agent, and includes one or more magnetic coils. The control device and the magnetic device are collectively configured to generate and apply a transient magnetic field to the treatment target to induce an electric field and porate the one or more cells and to permit the agent to enter the one or more cells.

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

The present invention is directed toward the use of non-thermal plasma-treated liquids as treatment options for herpes keratitis.

The present invention provides a method of preventing damage to non-neoplastic cells i.e. healthy cells by irradiating with a low-dose radiation to the non-neoplastic cells, wherein the low-dose radiation is used to initiate a protective cellular response which prevents later damage to non-neoplastic cells by cytotoxic chemical agents or chemo agents and initiating an immune response against neoplastic cells. The low-dose radiation is applied to the sensitive and the non-cancerous organs/cells at a given time before a high dose chemo/drug infusion session.

Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.

Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.

Disclosed are methods of treating a subject in need thereof comprising: applying alternating electric fields, at a frequency for a period of time, to a target site of the subject in need thereof; and administering one or more FGF inhibitors or FGFR inhibitors to the subject in need thereof. Disclosed are methods of increasing a cell's sensitivity to alternating electric fields comprising: applying alternating electric fields, at a frequency for a period of time, to a cell; and contacting one or more FGF inhibitors or FGFR inhibitors to the cell, thereby increasing the cell's sensitivity to the alternating electric fields. Disclosed are methods of increasing cytotoxicity in a cell comprising: applying alternating electric fields, at a frequency for a period of time, to a cell; and contacting one or more FGF inhibitors or FGFR inhibitors to the cell, thereby increasing cytotoxicity in the cell. Disclosed are methods of maintaining, or enhancing, sensitivity to alternating electrical fields in a cell comprising: applying alternating electric fields, at a frequency for a period of time, to a cell; and contacting one or more FGF inhibitors or FGFR inhibitors to the cell, thereby maintaining, or enhancing, sensitivity to the alternating electrical fields in the cell. In some aspects, maintaining, or enhancing, sensitivity of a cell to alternating electrical fields is the same as reducing resistance of the cell to alternating electrical fields.

Systems and methods are disclosed for inducing apoptosis and treating or reducing the occurrence of at least one condition, disease, disorder, or infection in a subject. The systems and methods rely on the application of an alternating electric field and administration of a clustered regularly interspaced short palindromic repeats (CRISPR) associated protein (CRISPR-Cas) system. Also provided are kits for performing the methods disclosed herein.