Various exemplary photoreactions can be provided, including reactions generally based on triplet-triplet annihilation upconversion. Representative photosensitizers include PdPc(OBu)8 and PtTPTNP. Representative annihilators include FDPP and TTBP. Such exemplary photoreactions, systems and methods may be used in a variety of applications, including various biological or physical applications. Exemplary methods can also be provided for making or using such systems, photoreactions, kits including such systems, or the like.

Crosslinkers of an amide or thiocarbamate of 7-nitroindoline were prepared with at least two attached reactive groups for crosslinking capability. The photo-cleavability of the invented crosslinkers is based on the known photolysis behavior of N-acyl-7-nitroindolines, and the photolysis behavior of amides and thiocarbamates of 7-nitroindolines. These crosslinkers enable crosslinking of biopolymers, which can be reversed by illumination with light.

There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

A light-controlled antibacterial agent composed of linear cationic oligopeptide and multi-arm -cyclodextrin that regulates antibacterial activity with light, belongs to the technical field of antibacterial materials. The light-controlled antibacterial agent with light response composed of linear cationic oligopeptide and multi-Arm -cyclodextrin of the present invention is cross-linked aggregates formed from linear cationic oligopeptide containing azobenzene and multi-arm cyclodextrin by host-guest recognition. The linear cationic oligopeptide and the multi-arm -cyclodextrin have significantly different antibacterial activities in two states of aggregation and deaggregation. The present invention uses the photoisomerization property of azobenzene conformation in the linear cationic oligopeptide to regulate the combination and dissociation of the host-guest recognition between azobenzene and cyclodextrin and to control the formation and disintegration of cross-linked aggregates so as to regulate the antibacterial activity of linear cationic oligopeptide with light.

Provided are conjugates comprising a carbon monoxide (CO)-releasing molecule (CORM) conjugated to a targeting moiety that binds to a cell surface molecule of a target cell. In certain embodiments, the CORM is a photoactivatable CORM (photoCORM). According to some embodiments, the target cell is a cancer cell, and the targeting moiety (e.g., an antibody) specifically binds a tumor antigen present on the cancer cell. Also provided are compositions comprising the conjugates of the present disclosure, and methods of using the conjugates of the present disclosure, e.g., to treat an individual having cancer.

The present invention relates to a cobalt-nitrosyl complex having photocleavable ligands. The cobalt-nitrosyl complex provided in one aspect of the present invention is adept in the delivery of NO, with exquisite temporal control using light, without gene editing. In addition, the complex provided in one aspect of the present invention is excellent in biocompatibility because it is chemically stable, non-toxic at cell level, and non-perturbative in cellular environments.

A platinum complex includes a structure of Formula (I). A method for treating a subject suffering from cancer includes a step of administering an effective amount of the platinum complex to the subject. A method for inhibiting the growth of cancer cells includes the step of contacting a population of cancer cells with an effective amount of the platinum complex. The platinum complexes are particularly suitable for treatment of cancer through, in particular, photodynamic therapy.

Embodiments of near-infrared light-cleavable heptamethine cyanine-based conjugates, particularly targeting agent-drug conjugates, according to Formula I and conjugate precursors are disclosed. The disclosed targeting agent-drug conjugates are useful for targeted delivery and release of a drug. Methods of making and using the conjugates and precursors also are disclosed. ##STR00001##

The present disclosure relates to novel radiation-triggered controlled release drug compositions, and methods to make and use the radiation-triggered controlled release drug compositions. The radiation-triggered controlled drug release nanoparticle formulations may be used to achieve maximum bioavailability and minimum adverse effects of the chemo drugs in chemo radio combination therapy treatment of locally advanced solid tumors.