A method for improving the ultrasonic transdermal delivery of an drug by modifying the excipient solution to which an active ingredient is intermixed in a drug formulation, whereby the choice of excipient solution is modified to one which will be more conducive to ultrasound and will propagate the drug substance at a higher delivery speed through the skin under ultrasonic excitation An example of such an excipient change includes a conversion from a standard dibasic sodium phosphate containing formulation to one using far less sodium or less preservative compositions. Reduced dibasic sodium phosphate formulation. Responsively to insonification thereof, including: reducing the amount of dibasic sodium phosphate in the formulation to provide a reduced dibasic sodium phosphate formulation; and, making a substance in accordance with the reduced dibasic sodium phosphate formulation.

Several embodiments disclosed herein relate to the delivery of therapeutic nucleic acids to an ocular tissue in order to provide a therapeutic effect to reduce symptoms of or otherwise alleviate an ocular disorder. In particular embodiments, plasmid DNA is delivered to the cells of the trabecular meshwork in order to ameliorate increasing intraocular pressure. Devices and systems to accomplish this delivery are also disclosed.

This invention refers to a device capable of rapidly and efficiently converting the energy in a laser pulse into a high-impulse broadband pressure wave and to its applications in the transient permeabilization of a biological membrane, including the outer layers of the skin, without causing damage or discomfort. A method to deliver drugs and biologically active compounds to or through the skin, or biological barriers, with this device is also disclosed.

Systems and methods of stimulating or activating fluids for use in wound treatment systems.

A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or re-mineralisation.

A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or re-mineralisation.

Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

Methods for treating nausea and migraine by iontophoretically administering triptan compounds are provided.

The present disclosure relates to a high density ultrasound coupling gel having improved ultrasound coupling, thermal transfer, drug delivery, and long duration ultrasound treatment. The high density ultrasound coupling gel includes a water-based ultrasound transmission gel material in a concentration amount of between about 90 and 99 weight percent (wt %) and a sodium dopant in a concentration amount of between about 1 and 10 wt %. The water-soluble ultrasound transmission gel material is effective to conduct acoustic energy. The sodium dopant is effective to increase density of the water-based ultrasound transmission gel material. The high density ultrasound coupling gel has a density of between about 1 and 2 grams per milliliter (g/mL). The present disclosure also relates to the use of the high density ultrasound coupling gel in ultrasound coupling devices, ultrasound systems, and methods of treatment such as long-duration ultrasound therapeutic treatment.

A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.