The present disclosure relates to a composition for transduction of a virus in a cell by using a crosslinked product of PEGylated magnetic nanoparticles and catechol grafted poly-L-lysine by application of an external magnetic field. When the composition is used, a virus may be delivered into cells more rapidly and efficiently than in intracellular uptake of a virus by CAR-mediated endocytosis.

The present invention relates to a method for effectively delivering an anticancer drug into cancer cells by binding the anticancer drug to pH-sensitive metal nanoparticles so as to be separated from cancer cells. The pH-sensitive metal nanoparticles according to the present invention may be heated by photothermal therapy, thereby effectively killing cancer cells in conjunction with the isolated anticancer drug.

Methods, system and reagents to treat cancer using magnetic particle are disclosed. The method comprises giving patient magnetic particle in combination with TLR agonist type composition and optionally later followed by immune check point inhibitor treatment at therapeutical effective amount. The magnetic particle and TLR agonist type composition is given by intratumoural injection.

UV-Laser-synthesized, fluorescent, spherical and magnetic nanoparticles are loaded Sophorolipid mesostructures useful for bio-imaging and therapeutic applications.

Provided herein are compositions including biocompatible magnetizeable nanoparticles. The nanoparticles have a diameter (average diameter) from about 10 to about 300 nanometers and are biocompatible and magnetic. The nanoparticles may be a disc formed from iron oxide. The disc may be conjugated to a target-binding moiety capable of binding a target. The target may be cancer cells, pathogens, fat cells, or atherosclerotic plaques.

A device for providing hyperthermia treatment includes an ultrasound energy generator configured to apply low intensity ultrasound to target tissue. The low intensity ultrasound energy induces therapeutic heating in the tissue at or below the surface of the skin. In order to control the temperature of the tissue during therapy, a microwave radiometer, such as a Dicke radiometer, can be used to measure the temperature of the tissue and feed back the temperature measurement to the ultrasound energy generator to control ultrasonic energy produced and control the temperature of the target tissue.

A method for increasing the release of at least one compound, the compound being initially an initial compound bound to at least one initial nanoparticle, the initial compound bound to the initial nanoparticle forming an initial particle, wherein the initial particle includes at least one active ingredient, the method including at least one step of alteration of the initial particle and at least one step of physico-chemical disturbance of an altered particle resulting from the alteration.

A carbon nanotube composite vector having a synergistic effect of photothermal therapy and gene therapy, a preparation method therefor, and an application thereof. The vector includes a vector moiety and a gene, and the vector moiety includes carbon nanotubes, a peptide lipid, and/or an additive. A modifier is immobilized on the carbon nanotubes by a self-assembly process to prepare the composite vector that can carry and transfer the gene. The composite vector overcomes the problems that pure carbon nanotubes have poor water solubility, low biocompatibility, and poor gene carrying and transfer efficiency; moreover, the composite vector has higher photothermal conversion performances and gene transfer efficiency, reduces cytotoxicity of carbon nanotubes, and alleviates the problem of localized accumulation of carbon nanotubes. The synergistic effect of photothermal therapy and gene therapy is applied to resolve the problem in tumor treatment that the efficacy of a single treatment method is poor.

Described herein is a method for producing ferrite nanocrystals. The method includes providing a solution including a fatty acid, an aliphatic amine and an alcoholic solvent, adding at least one organometallic precursor compound including a metal selected from the group consisting of Fe, Mn, Co and Zn and an aromatic organic molecule to the solution thereby obtaining a reaction mixture, transferring the reaction mixture to a sealed reactor, thereby obtaining a filling percentage of the sealed reactor between 20 and 70 vol. %, and heating the sealed reactor to a temperature between 160° C. and 240° C. for at least 3 hours.

A spiky metal organic framework is provided in the present disclosure. The spiky metal organic framework is formed by a coordination reaction between at least one metal ion and an organic ligand, and includes a body and a plurality of spike-like structures. The body is a spherical shape, and a particle size of the body is 1 μm to 3 μm. The spike-like structures are distributed on a surface of the body, a diameter of each spike-like structure is 15 nm to 35 nm, and a length of each spike-like structure is 250 nm to 400 nm.