The present disclosure is directed to systems, device and methods for cancer ablation treatment of human and animal subjects through the application of a combination of electromagnetic sources, in particular, microwave and radio frequency radiation that are focused on a tumor harboring magnetic or other metallic nanoparticles to result in synergetic heating effect whereby the tumor is heated to ablative temperature due to the strong absorption of the nanoparticles while the surrounding healthy tissue is hardly affected.

A method of closing an opening in a tissue comprises providing a light absorbing material, introducing the light absorbing material into a tissue opening, and irradiating the light absorbing material with at least one light source so as to increase a temperature of the light absorbing material, causing the tissue edges of the tissue opening adhere to the light absorbing material and/or to each other. A kit comprising a light absorbing material and a light emitting device is also described.

Provided are a system and a method for determining the temperature of a body by imaging a hydrogen proton-rich material positioned within the body using nuclear magnetic resonance imaging. A method to increase changes in the MRI signal strength as a function of temperature, thus improving temperature sensitivity, is also provided. The system and method employ polymers having mechanical stability and magnetic image brightness at low temperatures of between 0° C. and −65° C. or high temperatures of between +37° C. and +80° C.

Provided herein are conjugates of retrograde tracers and cell-deactivating agents useful in targeting the nerve cells' body (soma) of neurons that are associated with pain, spasm or tonus, as well as methods of controllable selective deactivating of these nerve cells and devices for executing the methods.

The field of the disclosure relates generally to cancer cell destruction and, more specifically, to cancer cell destruction by photo-magnetic irradiation mediated multimodal therapy using smart nanostructures.

An example implantable microparticle for delivering therapeutic heat treatment comprises a generally spherical body. The body may be formed from a first material comprising a biodegradable material and a second material comprising a Curie temperature material. The biodegradable material may be a non-Curie temperature material or have a Curie temperature lower than a Curie temperature of the Curie temperature material. The first material and the second material are mixed to form a composite having a Curie temperature in the range of 35° C. and 100° C.

The present invention provides a method for preparing iron oxide magnetic particles and iron oxide magnetic particles prepared thereby, wherein the method includes (a) synthesizing a complex by reacting iron and one or more compounds selected from the group consisting of an aliphatic hydrocarbonate having 4 to 25 carbon atoms and an amine compound, (b) synthesizing an iron oxide crystal nucleus by mixing the complex with a mixture of an unsaturated aliphatic hydrocarbon-based compound having 4 to 25 carbon atoms and an ether-based compound, and (c) forming a shell by mixing the iron oxide crystal nucleus and an MXn compound with a mixture of an unsaturated aliphatic hydrocarbon-based compound having 4 to 25 carbon atoms and an ether-based compound, wherein M is a heavy atom element, X is a halogen element, and n is an integer of 1 to 6.

A nanoagent for detections and treatments of multiple targets of interest includes multiple types of nanocomposites, each type of nanocomposites comprising at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a respective reporter assembled on the shell of each nanostructure; and a layer of a respective treating agent and a respective targeting agent conjugated to the respective reporter. In use, each type of nanocomposite targets to a respective target of interest according to the respective targeting agent and releases the respective treating agent and the nanostructure therein for therapeutic treatment of the respective target of interest, and the respective target of interest transmits at least one signature responsive to the respective reporter for detection of the respective target of interest.

The present invention provides iron oxide magnetic particles including an iron oxide and MX.sub.n, wherein M includes one or more selected from the group consisting of Cu, Sn, Pb, Mn, Ir, Pt, Rh, Re, Ag, Au, Pd, and Os, X includes one or more selected from the group consisting of F, Cl, Br, and I, and n is an integer of 1 to 6.

The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b) provide MRI contrast enhancement for MR-guided hyperthermia. The nanoparticles in the NLSC are non-toxic, and do not alter stem cell proliferation and differentiation, the nanoparticles do however, become heated in an alternating magnetic field, enabling therapeutic applications for cancer treatment. Due to the fact that circulating stem cells home to tumors and metastasis, and participate in neovascularization of growing tumors, the NLSC of the present invention allows tracking of the tissue distribution of infused stem cells and selective heating of targeted tissues with AMF. NLSC can deliver hyperthermia to hypoxic areas in tumors for sensitization of those areas to subsequent treatment, thus delivering therapy to the most treatment-resistant tumor regions. The heating of diseased tissue either results in direct cell killing or makes the tumor more susceptible to radio- and/or chemotherapy. The targeted hyperthermia provided by the present invention has clinical potential because it is associated with fewer side effects, and can also be used in combination with conventional treatment modalities, significantly enhancing their effectiveness. The NLSC of the present invention can be used for MR image-guided hyperthermia in oncology, in stem cell research for cell tracking and heating, and for elimination of mis-injected stem cells.