The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.

The present invention relates to a structure having a nanoantenna, a method for manufacturing same, a drug delivery body having the same, a thermotherapy complex, a drug therapy device, and a thermotherapy device. The structure of the present invention has a nanoantenna pattern formed on the outer surface of a porous micro-container, thereby enabling wireless control from the outside, and when the structure is used as a drug delivery system and a thermotherapy complex, drug therapy and thermotherapy can be carried out at a desired application region inside a living body at a desired time. Also, the structure of the present invention enables transmission and reception of a wireless signal with an external controller through the nanoantenna, thereby enabling the detection of a signal inside the living body and the transmission of the signal to the external controller, and the discharge of a drug or nanowires according to a response signal transmitted from the external controller.

A non-pyrogenic preparation containing nanoparticles synthesized by magnetotactic bacteria for medical or cosmetic applications. The nanoparticles are constituted by a crystallized mineral central part including predominantly an iron oxide, as well as a surrounding coating without material from the magnetotactic bacteria.

Provided are a nanoparticle complex for oral administration, a pharmaceutical composition for oral administration for treating brain tumors, including the same, a pharmaceutical composition for oral administration for photothermal therapy (PTT) or photodynamic therapy (PDT), and a method of treating brain tumors using the pharmaceutical composition, and the nanoparticle complex for oral administration has not only excellent metal-enhanced fluorescence (MEF) but also excellent metal-enhanced reactive oxygen generation (MERos) due to a surface plasma resonance effect through a bond with the photosensitizer while having excellent oral absorption rate through a bond with lactoferrin, and when a pharmaceutical composition including the nanoparticle complex is administered, the pharmaceutical composition can effectively permeate the small intestinal epithelium and the blood-brain barrier without toxicity and can be effectively accumulated in brain tumor tissue to have an excellent photothermal therapy (PTT) or photodynamic therapy (PDT) effect in brain tumor tissue. In addition, there is an advantage in that brain tumors can be effectively treated by adjusting the order of photothermal therapy (PTT) and photodynamic therapy (PDT), and the like after administering a pharmaceutical composition including a nanoparticle complex for oral administration.

A heat-sensitive system comprising at least one nanoparticle bound covalently to at least one thermolabile molecule comprising an azo —N═N— functional group —N═N— in turn bound covalently to at least one active molecule selected from a fluorophore molecule and a drug is disclosed. The system converts an electromagnetic radiation into thermal energy exposed to an alternating magnetic field. Uses of the system are also disclosed.

Described herein are methods for delivering an anti-cancer agent to a tumor in a subject. The method involves administering to the subject (i) gold particles and (ii) at least one-anti-cancer agent directly or indirectly bonded to the macromolecule and/or unbound to the macromolecule; and exposing the tumor to light for a sufficient time and wavelength in order for the gold particles to achieve surface plasmon resonance and heating the tumor.

The disclosure relates to a two-dimensional (2D) bismuth nanocomposite, and a preparation method and use thereof, and belongs to the field of nanobiotechnology. The 2D bismuth nanocomposite of the disclosure is an ultra-thin bismuth nanosheet that is loaded with platinum nanoparticles and modified with indocyanine green (ICG) and surface targeting polypeptide Ang-2. The 2D bismuth nanocomposite Bi@Pt/ICG-Ang2 of the disclosure can not only realize the targeted photothermal and photodynamic combination therapy for tumors, but also realize the dual-mode imaging combining CT and fluorescence imaging.

A method of making and using a medical delivery device includes forming a first compartment to contain at least a portion of an activator, where forming the first compartment includes forming a first wall with a first ferrous material such that the first wall disintegrates in response to first electromagnetic radiation received by the first ferrous material. Upon contact, the activator activates one or more molecular nanomachines. The method also includes forming a second compartment adjacent to the first wall of the first compartment to contain the one or more molecular nanomachines. The second compartment includes a second wall that includes a second ferrous material. The second wall is configured to disintegrate and release one or more activated molecular nanomachines into a patient in response to second electromagnetic radiation received by the second ferrous material.

One or more techniques and/or products are disclosed using a process for preparing metallic nanoparticles. Resulting nanoparticles may comprise a gold-silver-gold core-shell-shell nanoparticles. Such nanoparticles can be formed by forming a gold core, providing certain materials to form a silver shell, and providing certain materials to form a gold shell. The metallic nanoparticles may be used in molecular sensing, catalysis, photothermal therapy, and other biologically-relevant technologies.

This invention provides block copolymer (BCP) encapsulated nanoparticles. The BCP-encapsulated nanoparticles are used in methods for targeting a tumor, in methods of imaging a tumor and in methods of treating cancer including hyperthermia of tumors. This invention further provides processes for preparation of BCP-encapsulated nanoparticles.