Zr-based metal-organic frameworks (Zr-MOFs) independently comprising the following formula and/or structure: Zr.sub.6O.sub.4(OH).sub.4(polycarboxylate).sub.6, and methods of making and using same. In various examples, a method produces a Zr-MOF or Zr-MOFs. In various examples, a Zr-MOF is a hydrogen sulfide (H.sub.2S)-loaded Zr-MOF. In various examples, a method produces a (H.sub.2S)-loaded Zr-MOF or (H.sub.2S)-loaded Zr-MOF. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H.sub.2S to an aqueous environment, a solvent, or the like. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H.sub.2S to an aqueous environment, a solvent, or the like. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H.sub.2S to an individual, such as, for example, an individual suffering from or at risk of an ischemia-reperfusion injury, inflammation, a wound, or the like, or any combination thereof.

Zr-based metal-organic frameworks (Zr-MOFs) independently comprising the following formula and/or structure: Zr.sub.6O.sub.4(OH).sub.4(polycarboxylate).sub.6, and methods of making and using same. In various examples, a method produces a Zr-MOF or Zr-MOFs. In various examples, a Zr-MOF is a hydrogen sulfide (H.sub.2S)-loaded Zr-MOF. In various examples, a method produces a (H.sub.2S)-loaded Zr-MOF or (H.sub.2S)-loaded Zr-MOF. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H.sub.2S to an aqueous environment, a solvent, or the like. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H.sub.2S to an aqueous environment, a solvent, or the like. In various examples, a Zr-MOF or Zr-MOFs is/are used to deliver H.sub.2S to an individual, such as, for example, an individual suffering from or at risk of an ischemia-reperfusion injury, inflammation, a wound, or the like, or any combination thereof.

Compositions, methods, devices, and systems are provided comprising a polymer having one or more sensors.

Compositions, methods, devices, and systems are provided comprising a polymer having one or more sensors.

Compositions include highly concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).

Compositions include highly concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).

The present disclosure provides compositions and methods for intra-articular delivery of anti-CSF1R antibodies to a tissue that is impacted by a disease that is treatable with CSF1/CSF1R inhibition and/or that expresses CSF1R. It was conventional knowledge that the intra-articular dwell time of proteins in joints is typically a few hours or less. The present disclosure shows, however, that intra-articular delivery of an anti-CSF1R antibody can lead to sustained exposure and pharmacologic activity of the antibody in the joints far beyond a few hours, providing an effective means for targeted and extended delivery of the therapeutic agent.

Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.