The present invention relates to compounds comprising denatonium linked to the C-terminus of a protease-sensitive peptide; or a salt thereof. The compounds are useful in the diagnosis of inflammatory conditions of the oral cavity.

The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.

Methods of identifying a xenohormetic induced phenotype in an organism are provided. Also provided are methods if using organisms having a known xenohormetically induced phenotype in a number of different applications, such as the identification of xenohormetic agents and the generation of chemical entities and foodstuffs under specific conditions of production governed by xenohormetic effects.

A method of assessing the impact of a test oral care flavour composition on the well-being of human subjects is provided, as well as a method of preparing or optimizing an oral care flavour composition for enhancing the well-being of a human subject, oral care flavour compositions that enhance the well-being, and consumer products containing them.

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

The present invention relates to compositions and methods of use of anti-ADAMTS13 autoantibodies and fragments thereof. In one aspect, the invention includes a composition comprising an isolated anti-ADAMTS13 autoantibody or fragment thereof. In other aspects, methods are described for generating an in vivo model of thrombotic thrombocytopenic purpura (TTP) comprising introducing at least one anti-ADAMTS13 autoantibody or fragment thereof into a model organism and identifying an anti-autoimmune reagent for treating TTP.

This disclosure provides reagents and methods of predicting the responsiveness of a patient to NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates).

A method of inhibiting GAPDH with N-methylol transfer agents and/or related compounds.

A method for inducing a hibernation-like state and a device for the same is described. The method is a chemical and physical method for reducing, in a subject, a theoretical set-point temperature of a body temperature and/or a feedback gain of heat production, or for inducing a hibernation-like state in the subject, the method including applying an excitatory stimulus to pyroglutamylated RFamide peptide (QRFP)-producing neurons. A device used to implement the method is also described.

The present invention provides a novel milk allergy antigen, a milk allergy diagnosis method or diagnosis kit, a composition comprising the antigen, a milk or processed milk product with the antigen removed, and a tester composition for determining the presence or absence of the milk antigen in an object of interest. The present invention also pertains to an antigen epitope-comprising polypeptide, a kit for diagnosing an allergy comprising the polypeptide, diagnostic composition, a diagnosis method, a composition comprising the polypeptide, and a raw material or processed product in which the polypeptide-comprising antigen is eliminated or reduced. The present invention further pertains to a tester composition for determining the presence or absence of an antigen in an object of interest.