An aqueous ultrasound contact fluid includes a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and the use of the ultrasound contact fluid in an intraoperative or interventional ultrasound imaging procedure. A method for intraoperative ultrasound imaging includes filling an aqueous ultrasound contact fluid into a body cavity. The aqueous ultrasound contact fluid is a composition comprising a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and optionally a pharmaceutically acceptable humectant, and the triglyceride content is in the range of 8-240 g/1000 ml composition contact fluid and the amount of emulsifier is 0.4-18 g/1000 ml composition contact fluid, and optionally a humectant in the amount of 1.2-30 g/1000 ml. The method further includes obtaining an ultrasound image of a body region that comprises at least part of the body cavity filled with the aqueous ultrasound contact fluid. The aqueous ultrasound contact fluid reduces image artifacts associated with the body cavity.

An aqueous ultrasound contact fluid includes a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and the use of the ultrasound contact fluid in an intraoperative or interventional ultrasound imaging procedure. A method for intraoperative ultrasound imaging includes filling an aqueous ultrasound contact fluid into a body cavity. The aqueous ultrasound contact fluid is a composition comprising a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and optionally a pharmaceutically acceptable humectant, and the triglyceride content is in the range of 8-240 g/1000 ml composition contact fluid and the amount of emulsifier is 0.4-18 g/1000 ml composition contact fluid, and optionally a humectant in the amount of 1.2-30 g/1000 ml. The method further includes obtaining an ultrasound image of a body region that comprises at least part of the body cavity filled with the aqueous ultrasound contact fluid. The aqueous ultrasound contact fluid reduces image artifacts associated with the body cavity.

We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.

There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.

This invention provides poly(alkylene carbonate)-based amphiphilic block copolymers, compositions comprising the same, e.g., micelles, and methods of use thereof. This invention further provides methods for preparing the poly(alkylene carbonate)-based amphiphilic block copolymers of the invention.

Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.

Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.

Disclosed is a targeted molecular imaging probe consisting of a signal component, a component with a targeted affinity to Cx43 and a linker. The biochemical variation characteristic of connexin43 (Cx43) associated with cardiovascular diseases (especially arrhythmia) and neoplastic diseases can be reflected in the form of an image by using the targeted molecular imaging probe capable of being detected by an imaging device, to achieve in vivo molecular imaging.

The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.

The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.