The aim of the invention is to provide preparations and extracts of lemon verbena (Aloysia citriodora, or its synonyms) for the prophylaxis of mental stress, for increasing cognitive performance and for treating ADHS. For this purpose, preparations and extracts of lemon verbena (Aloysia citriodora, or its synonyms) are used, particularly in the form of hydroalcoholic extracts. These extracts can be used in food products, food supplements, supplementary balanced diets or pharmaceutical preparations.

An ovarian care formula containing A-SDGPLUS and a preparation method therefor are provided, belonging to the technical field of ovarian care. The ovarian care formula containing A-SDGPLUS is prepared from the following raw materials in percentage by mass: 30%-50% of postbiotics, 15%-25% of chasteberry extract and 5%-10% of flaxseed lignan. The preparation method for the ovarian care formula containing A-SDGPLUS includes the following steps: mixing postbiotics, a chasteberry extract and flaxseed lignan in percentage by mass described above, evenly stirring, and packaging to obtain an ovarian care solid drink. The ovarian care formula is composed of postbiotics, the chasteberry extract and flaxseed lignan, which can be directly taken to act on ovary, with quick effect and no side effects.

The current methods and compositions provide for a novel and effective therapeutic method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain. Accordingly, certain aspects of the disclosure relate to a method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain in a subject, the method comprising administering at least one purified cannabinoid compound and a partial opioid agonist. In some embodiments, the method comprises administering a composition comprising cannabidiol and buprenorphine.

A cream formulation or topical use made of a mixture of naturally occurring biologically active phytochemical compounds that possess a variety of beneficial animal and human health effects. An extract from an aqueous extraction process or other active ingredients could be used in the cream formulation. The present invention generally provides for the preparation of cream formulations containing active ingredients that contain individually, or in combination, an analgesic, natural product extracts, or a protein or proteins from the tripartite motif family of proteins (TRIM). The analgesic will provide mitigation of pain during the healing process.

The aim of the invention is to provide preparations and extracts of lemon verbena (Aloysia citriodora, or its synonyms) for the prophylaxis of mental stress, for increasing cognitive performance and for treating ADHS. For this purpose, preparations and extracts of lemon verbena (Aloysia citriodora, or its synonyms) are used, particularly in the form of hydroalcoholic extracts. These extracts can be used in food products, food supplements, supplementary balanced diets or pharmaceutical preparations.

It is an object of the invention to provide an MDA concentration decrease accelerator, an 8-OHdG concentration decrease accelerator, a ZIP4 concentration increase accelerator, or a serum zinc concentration increase accelerator for the jejunum that can accelerate a decrease in MDA concentration, a decrease in 8-OHdG concentration, an increase in ZIP4 concentration, and an increase in serum zinc concentration for the jejunum to improve an oxidative stress state. The invention includes 3,5-dihydroxy-4-methoxybenzyl alcohol as an active ingredient and has an 8-OHdG concentration decrease accelerative action of decreasing a jejunal 8-OHdG concentration.

The invention relates to the use of an extract of Phaeodactylum tricornutum alone or in combination with an extract chosen from a guarana (Paullinia cupana) extract, a ginseng (Panax ginseng) extract, a Ginkgo biloba extract, a Nelumbo nucifera extract, a Centella asiatica extract, a Piper nigrum extract, a Bacopa monnieri extract or any combination thereof and/or a compound chosen from arginine, creatine, caffeine, theanine, vitamin C, vitamin E, vitamin B, theophylline, paraxanthine, theobromine, rosmarinic acid, ellagic acid, cinnamaldehyde or any combination thereof, for maintaining and/or increasing data processing speed and/or concentration in healthy mammals. The combination of the extract of P. tricornutum and one of these extracts or one of these compounds is also described. The invention also relates to a composition comprising the combination according to the invention.

Extraction method comprising an extraction step, during which a plant substrate is caused to come into contact with an aqueous liquid so that cannabinoids are extracted from the plant substrate and carried to the aqueous liquid; the aqueous liquid comprises at least 40% by weight, relative to the total weight of the aqueous liquid, of water and a complexing component; the complexing component is at least one cyclodextrin; the composition obtained is surprisingly stable and the cannabinoids extracted, in particular the acid cannabinoids, which are normally unstable, can be conserved for long periods of time.

The current methods and compositions provide for a novel and effective therapeutic method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain. Accordingly, certain aspects of the disclosure relate to a method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain in a subject, the method comprising administering at least one purified cannabinoid compound and a partial opioid agonist. In some embodiments, the method comprises administering a composition comprising cannabidiol and buprenorphine.

TRIM72, is a naturally occurring protein in mammalian cells that is known to be important in cell membrane repair and tissue regeneration in injury conditions. When tissues are damaged, (abrasions, cuts, scrapes, etc.), the protein is recruited to the damaged tissue to aid in reassembly of the lipid membrane layer through shuttling membrane vesicles. The more quickly the cell membrane can be repaired, possibly even saving the damaged cells, the faster the full healing process will occur. This also greatly reduces the risk of infection by minimizing the length of time the damaged cells are exposed to the outside world. Rather than waiting for the protein to be naturally produced and recruited to the injury site, a topical application of the purified protein, either directly or contained as an active ingredient within a hydrogel or cream, could be applied, delivering the protein in high quantities directly to the affected area.