A system of assessing health status of manufacturing equipment includes codebook database, historical data database, a modeling server and an edge computing server. The codebook database stores multiple monitor parameter of the manufacturing equipment in each manufacturing process. The historical data database stores instant high-frequency data of all parameters of the manufacturing equipment, thereby providing historical high-frequency data of all parameters of the manufacturing equipment. The modeling database accesses historical high-frequency data of multiple monitor parameters from the historical data database according to the codebook data and extracts characteristics of the historical high-frequency data of multiple monitor parameters for constructing the health model of the manufacturing equipment. The edge computing server analyzes the instant high-frequency data uploaded by the manufacturing equipment during a current manufacturing process and the health model on a real-time basis, thereby generating a health index score of the manufacturing equipment during the current manufacturing process.