An antimicrobial suture comprising a filament and taurolidine.

The present invention provides an apparatus and method for creating hemostasis at a subcutaneous vascular puncture. The method and apparatus is intended, but not limited to, vascular punctures following trans-radial arterial procedures, e.g. catheterization and percutaneous coronary intervention.

The present invention provides an apparatus and method for creating hemostasis at a subcutaneous vascular puncture. The method and apparatus is intended, but not limited to, vascular punctures following trans-radial arterial procedures, e.g. catheterization and percutaneous coronary intervention.

The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10.Math. in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers. The disclosed methods enable a relatively simple way of providing a complex shaped article like a fibrous article with a bioceramic coating, to result in a modified surface that shows bioactivity, applying biocompatible compounds and mild conditions. The method can be used to make a polyester fibrous article having a coating with bioactive inorganic particles like calcium phosphates to enhance bone growth on the article after implantation. The disclosure also concerns a fibrous article showing osteoconductive properties, as obtainable with or obtained by said methods, and use of these articles as a component of a medical implant, especially of permanent high-strength orthopedic implants

The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10.Math. in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers. The disclosed methods enable a relatively simple way of providing a complex shaped article like a fibrous article with a bioceramic coating, to result in a modified surface that shows bioactivity, applying biocompatible compounds and mild conditions. The method can be used to make a polyester fibrous article having a coating with bioactive inorganic particles like calcium phosphates to enhance bone growth on the article after implantation. The disclosure also concerns a fibrous article showing osteoconductive properties, as obtainable with or obtained by said methods, and use of these articles as a component of a medical implant, especially of permanent high-strength orthopedic implants

The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10.Math. in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers. The disclosed methods enable a relatively simple way of providing a complex shaped article like a fibrous article with a bioceramic coating, to result in a modified surface that shows bioactivity, applying biocompatible compounds and mild conditions. The method can be used to make a polyester fibrous article having a coating with bioactive inorganic particles like calcium phosphates to enhance bone growth on the article after implantation. The disclosure also concerns a fibrous article showing osteoconductive properties, as obtainable with or obtained by said methods, and use of these articles as a component of a medical implant, especially of permanent high-strength orthopedic implants

A method for making an expanded, and optionally multi-component and/or colored PTFE monofilament is disclosed. The method includes forming a first paste by mixing a PTFE powder with a hydrocarbon solvent; forming an extrusion preform by pressing the first paste into a form; curing the extrusion preform by exposing the extrusion preform to a first temperature for a first time duration; forming a green monofilament by extruding the first paste through a die; expanding the green monofilament by exposing the green monofilament to a second temperature for a second time duration, the second time duration occurring after the first time duration; stretching the green monofilament substantially along a longitudinal axis of the green monofilament, the stretching the green monofilament occurring after the expanding the green monofilament; and sintering the green monofilament after the stretching the green monofilament.

A method for making an expanded, and optionally multi-component and/or colored PTFE monofilament is disclosed. The method includes forming a first paste by mixing a PTFE powder with a hydrocarbon solvent; forming an extrusion preform by pressing the first paste into a form; curing the extrusion preform by exposing the extrusion preform to a first temperature for a first time duration; forming a green monofilament by extruding the first paste through a die; expanding the green monofilament by exposing the green monofilament to a second temperature for a second time duration, the second time duration occurring after the first time duration; stretching the green monofilament substantially along a longitudinal axis of the green monofilament, the stretching the green monofilament occurring after the expanding the green monofilament; and sintering the green monofilament after the stretching the green monofilament.

A method for making an expanded, and optionally multi-component and/or colored PTFE monofilament is disclosed. The method includes forming a first paste by mixing a PTFE powder with a hydrocarbon solvent; forming an extrusion preform by pressing the first paste into a form; curing the extrusion preform by exposing the extrusion preform to a first temperature for a first time duration; forming a green monofilament by extruding the first paste through a die; expanding the green monofilament by exposing the green monofilament to a second temperature for a second time duration, the second time duration occurring after the first time duration; stretching the green monofilament substantially along a longitudinal axis of the green monofilament, the stretching the green monofilament occurring after the expanding the green monofilament; and sintering the green monofilament after the stretching the green monofilament.

Processes for making high-performance polyethylene multi-filament yarn are disclosed which include the steps of a) making a solution of ultra-high molar mass polyethylene in a solvent; b) spinning of the solution through a spinplate containing at least 5 spinholes into an air-gap to form fluid filaments, while applying a draw ratio DR.sub.fluid; c) cooling the fluid filaments to form solvent-containing gel filaments; d) removing at least partly the solvent from the filaments; and e) drawing the filaments in at least one step before, during and/or after said solvent removing, while applying a draw ratio DR.sub.solid of at least 4, wherein in step b) each spinhole comprises a contraction zone of specific dimension and a downstream zone of diameter Dn and length Dn with Ln/Dn of from 0 to at most 25, to result in a draw ratio DR.sub.fluid=DR.sub.sp*DR.sub.ag of at least 150, wherein DR.sub.sp is the draw ratio in the spinholes and DR.sub.ag is the draw ratio in the air-gap, with DR.sub.sp being greater than 1 and DR.sub.ag at least 1. High-performance polyethylene multifilament yarn, and semi-finished or end-use products containing said yarn, especially to ropes and ballistic-resistant composites, are also disclosed.