Disclosed are medical devices, e.g., surgical sutures, surgical staples, surgical pads, surgical meshes, surgical scaffolds etc., and methods of use at a wound in a patient to facilitate the rapid healing of the tissue at the situs of the wound with minimal fibrous tissue formation. The devices are arranged to be brought into engagement with tissue adjacent the wound to close the Wound and include a core formed of a piezo-electric material and an outer layer covering the core. The outer layer is platelet derived growth factors. The methods of use of the devices also include applying a local molecular energy production agent to the wound and irradiating the wound with a pulsed infra-red laser beam.

The present invention provides a surgical thread, comprising a modified cross-section fiber, wherein the modified cross-section fiber is in a twisted state. The surgical thread of the present invention has advantages of good coefficient of kinetic friction, good tensile strength, good elongation rate and good softness, and good safety, comprising no inflammatory potential, no cytotoxicity, no pyrogen, no acute systemic toxicity and no intradermal irritation potential, and has the efficacy of promotion of collagen formation, thereby being suitable for embedding in the face. The present invention further provides a cosmetic treatment and a manufacturing method for the surgical thread.

The present invention provides a surgical thread, comprising a modified cross-section fiber, wherein the modified cross-section fiber is in a twisted state. The surgical thread of the present invention has advantages of good coefficient of kinetic friction, good tensile strength, good elongation rate and good softness, and good safety, comprising no inflammatory potential, no cytotoxicity, no pyrogen, no acute systemic toxicity and no intradermal irritation potential, and has the efficacy of promotion of collagen formation, thereby being suitable for embedding in the face. The present invention further provides a cosmetic treatment and a manufacturing method for the surgical thread.

Bioresorbable zinc-based (i.e., Zn-based) wound closure devices are provided. The Zn-based wound closure devices include Zn and at least one primary alloying element (i.e., Cr, V and/or Zr). The Zn-based wound closure devices are biocompatible with good mechanical strength and tissue compatibility. The Zn-based wound closure devices are safe and easy to use during surgical operations and provide shorter recovery and healing time with less chance of clinical complications. Typical applications for Zn-based wound closure devices include skin wound closure, muscular, vascular, and neuronal anastomosis, as well as GI anastomosis and other tissue or organ anastomosis. The Zn-based wound closure devices can be used for treatment of the above applications for pediatric patients.

Bioresorbable zinc-based (i.e., Zn-based) wound closure devices are provided. The Zn-based wound closure devices include Zn and at least one primary alloying element (i.e., Cr, V and/or Zr). The Zn-based wound closure devices are biocompatible with good mechanical strength and tissue compatibility. The Zn-based wound closure devices are safe and easy to use during surgical operations and provide shorter recovery and healing time with less chance of clinical complications. Typical applications for Zn-based wound closure devices include skin wound closure, muscular, vascular, and neuronal anastomosis, as well as GI anastomosis and other tissue or organ anastomosis. The Zn-based wound closure devices can be used for treatment of the above applications for pediatric patients.

Suture materials for producing medical devices are provided. The suture materials can include natural fibers, and can be suitable for making multifilament sutures and surgical meshes comprising multifilament sutures as examples of medical devices. The multifilament suture can include a plurality of filaments combined together according to a twined pattern, and at least one filament of the plurality of filaments can include natural fibers, synthetic fibers, or mineral-based fibers. A suture device can include the multifilament suture combined with a suture needle. The multifilament suture can be coated with a biocompatible coating, such as a bioactive agent, and/or include a first set of filaments that includes natural fibers and a second set of filaments that includes natural fibers that are different from the natural fibers of the first set of filaments, synthetic fibers or mineral-based fibers, for instance.

Suture materials for producing medical devices are provided. The suture materials can include natural fibers, and can be suitable for making multifilament sutures and surgical meshes comprising multifilament sutures as examples of medical devices. The multifilament suture can include a plurality of filaments combined together according to a twined pattern, and at least one filament of the plurality of filaments can include natural fibers, synthetic fibers, or mineral-based fibers. A suture device can include the multifilament suture combined with a suture needle. The multifilament suture can be coated with a biocompatible coating, such as a bioactive agent, and/or include a first set of filaments that includes natural fibers and a second set of filaments that includes natural fibers that are different from the natural fibers of the first set of filaments, synthetic fibers or mineral-based fibers, for instance.

An apparatus for forming a weld between a first portion of a biocompatible conductive thermoplastic material and a second portion of a biocompatible conductive thermoplastic material comprises a first electrode, a second electrode, and a structure for holding said first and second electrodes in opposition to one other with a space therebetween for receiving said first portion and said second portion in contact with one another. The structure is electrically non-conductive and an electrical circuit comprising a power source and a switch arranged such that closure of said switch applies a voltage potential across said first electrode and said second electrode so as to generate heat via electrical resistance, the heat being sufficient to melt regions of said first and second portions.

An apparatus for forming a weld between a first portion of a biocompatible conductive thermoplastic material and a second portion of a biocompatible conductive thermoplastic material comprises a first electrode, a second electrode, and a structure for holding said first and second electrodes in opposition to one other with a space therebetween for receiving said first portion and said second portion in contact with one another. The structure is electrically non-conductive and an electrical circuit comprising a power source and a switch arranged such that closure of said switch applies a voltage potential across said first electrode and said second electrode so as to generate heat via electrical resistance, the heat being sufficient to melt regions of said first and second portions.

Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.