The present disclosure relates to a method of forming yarns and preparing surgical devices therefrom. The yarns include at least one first filament possessing a polymer core and first reactive members known to have click reactivity on a surface thereof and at least one second filament possessing a polymer core and second reactive members known to have click reactivity on a surface thereof. The first and second reactive members are complementary such that they interact to covalently bond the filaments together.

The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

Provided are a method of manufacturing a hyaluronate-coated high-functional suture and a high-functional suture manufactured thereby, and more particularly to a method of manufacturing a high-functional suture and a high-functional suture manufactured thereby, wherein a suture for internal and external surgery derived from a conventional chemical synthetic material is coated with a hyaluronate as a biocompatible material, thus improving biocompatibility, functionality and ease of use.

The present disclosure is directed to a class of fluorinated copolymers, such as PTFE copolymers, that can be dissolved in low toxicity solvents, such as Class III Solvents, and that enable the creation of stable water-in-solvent emulsions comprising the fluorinated copolymers dissolved in a low toxicity solvents and a hydrophilic agent (e.g., a therapeutic agent) dissolved in an aqueous solvent, such as water or saline.

A suture anchor includes an anchor body having a longitudinal axis, a proximal end, and a distal end. The anchor body includes a central bore located at the proximal end and a passage extending between the central bore and the distal end. The central bore has a first dimension substantially perpendicular to the longitudinal axis, and the passage has a second dimension substantially perpendicular to the longitudinal axis less than the first dimension. The suture anchor includes a flexible strand extending through the passage, and a first knot formed in the flexible strand at the distal end has a third dimension greater than the second dimension to prevent the first knot from passing through the passage. A closed loop is positionable at least partially within the central bore and formed entirely by the flexible strand without forming any additional knots on the flexible strand extending proximally from the first knot.

Medical constructs with twisted cables formed from a plurality of collagen fibers twisted together to form strands and those strands twisted together to form cables and relate methods of twisting the collagen fibers to form the medical constructs while holding the fibers and strands of fibers in tension and twisting in a first direction (i.e., in a clockwise direction), then twisting them in a second opposing (counterclockwise) direction for a number of twists per inch.

A biodegradable stent and a method for preparing the same, which more particularly relate to a technology of preparing a biodegradable stent with improved flexibility and mechanical strength. The method includes a step of solid-state drawing a biodegradable filament and a step of shaping and then annealing the drawn biodegradable filament.

A suture including at least one filament formed of at least one polymer and at least one copper ion at least partially embedded in the at least one filament in a manner such that the at least one copper ion is released from the at least one filament over time.

The present invention relates to a modified polymeric material. The modified polymeric material includes a polymer having a modified surface, where the modified surface includes nano, micron, and/or submicron scale features. The present invention also relates to an implant comprising the modified polymeric material. The present invention further relates to processes for making the modified polymeric material and the implant.

The present invention relates to a modified polymeric material. The modified polymeric material includes a polymer having a modified surface, where the modified surface includes nano, micron, and/or submicron scale features. The present invention also relates to an implant comprising the modified polymeric material. The present invention further relates to processes for making the modified polymeric material and the implant.