The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.

Described are a method for producing cellulose fibers suitable for use in a thickening composition, a method for producing a thickening composition that contains the cellulose fibers, and a method for thickening a composition. The method for producing the cellulose fibers includes grinding a composition containing cellulose fibers and an aqueous solution to produce a dispersion containing cellulose fibers having an average fiber diameter (D) in a range of from 0.001 to 100 m in the aqueous solution.

A therapeutic preparation and article treated with tourmaline nano-particles and a method of manufacturing the same. The therapeutic preparation comprises a gel and tourmaline nano-particles held in suspension in said gel. The therapeutic article comprises a fabric and tourmaline particles attached to said fabric. In one embodiment, an adhesive containing tourmaline is applied to non-treated fabric to form the article. In another embodiment, the tourmaline is integral to the fabric. A method of manufacturing the therapeutic article comprises the steps of submerging a fabric in an aqueous solution comprising tourmaline nano-particles and drying said fabric.

Provided herein is a antimicrobial sorption composition containing pyrogenic silica and serrathiopeptidase useful for the treatment of wounds such as festering wounds, necrotic wounds, exudative wounds, or wounds with inflammatory infiltration.

A composite antibacterial hydrogel dressing, a preparation method and an application method thereof are provided, which relate to the field of biomedical technologies. The composite antibacterial hydrogel dressing is made from the following raw materials in parts by weight: 8 to 22 parts of chitosan, 12 to 36 parts of carrageenan, 9 to 25 parts of 2-aminoisonicotinic acid, 3 to 8 parts of lactic acid, 4 to 10 parts of iodine and 6 to 15 parts of potassium iodide. The composite antibacterial hydrogel dressing has a good flexibility, a strong antibacterial effect, a long antibacterial time, no skin irritation, good application prospect in the field of medical wound repair, simple preparation process and easy industrial production.

Described herein are oxygen-enriched tamponade compositions comprising silicone oil or a perfluorocarbon and methods of their use in the repair of retinal detachment. Post-operative repair for retinal detachment can include enhanced wound healing as the result of the administration of the compositions described herein. The enhanced wound healing can include rescue of ischemic retinal tissue, surgery induced hypoxia, and reduction of unwanted scar tissue development and prevention of re-detachment of the retina after surgical repair.

Inert hydrogels play a crucial role in burn first aid. If there is no access to clean water or if the burns are severe, hydrogel dressings may be used to cool burn wounds instead of running water. This is especially helpful in situations when clean water is not available. Hydrogels that have a high percentage of water content can dissipate the heat that builds up on the skin. In addition to relieving the discomfort, this will keep the area clean and protected from any additional injury.

The manufacture of bimetallic AgNi nanoparticles from a plant extract is at the core of the present invention. These nanoparticles are then incorporated into a PVA/AA hydrogel that is of a quality suitable for medical use. Since the nanoparticles in hydrogel possess antibacterial qualities, the combination may be used to speed up the healing process. The PVA/AA polymer of medical grade that was used in the production of the hydrogels does not irritate the skin and is not harmful to the environment. To produce NiAg nanoparticles in a PVA/AA matrix, we employed one pot green synthesis method. For the purpose of assisting in the speedy recovery of burn wounds and providing protection against E. coli, they operate as antibacterial agents that are extremely effective due to the size of the particles, which is 12 nm.

A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent is in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.

A material or biomaterial comprising silicic acid condensates having a low degree of cross-linking, and methods for its production are subject-matter of the invention. A method for the production of silicic acid structures having a low degree of cross-linking is disclosed, wherein a sol is produced, wherein further condensation is prevented when specific cross-linking of the silicic acid is reached, wherein, preferably, structures having a size of 0.5-1000 nm are produced, e.g. polyhedral structures or aggregates of the same. Further condensation can be prevented by means of mixing with a polymer. In one embodiment, this comprises nano-structured, silicon dioxide (SiO.sub.2) having a low degree of cross-linking that is embedded in a polymer matrix. The material can be used in medicine for therapeutic purposes, and can enter into direct contact with biological tissue of the body in this connection. This material herein enters into chemical, physical, and biological interactions with the corresponding biological systems. It can herein be decomposed, and can act as a supplier for the silicic acid required for metabolism. Furthermore, it can have a supportive or shielding effect. It can be present as a granulate, microparticles, fiber, and as a woven or nonwoven fabric produced therefrom, or as a layer on implants or wound dressings. The material can be used as a medical device or as a nutritional supplement.

A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof, which include introducing Na.sub.2O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCl, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.