Antigen-binding molecules (ABMs) that bind to Porphyromonas gingivalis are described. The ABMs may be human or humanized ABMs. The ABMs find use in treating infections involving P. gingivalis, such as periodontal disease. Also provided are methods of treating or preventing a disorder or disease by administering the ABM.

The present invention is directed to a hemostatic material comprising a compacted, hemostatic aggregates of cellulosic fibers. In some aspects, the hemostatic material further includes additives, such as carboxymethyl cellulose (CMC) or other polysaccharides, calcium salts, anti-infective agents, hemostasis promoting agents, gelatin, collagen, or combinations thereof. In another aspect, the present invention is directed to a method of making the hemostatic materials described above by compacting a cellulosic-based material into hemostatic aggregates. In another aspect, the present invention is directed to a method of treating a wound by applying hemostatic materials described above onto and/or into the wound of a patient.

The present invention relates to a haemostatic material comprising a carrier layer and a material for wound contact comprising at least one haemostat in particulate, granular, powder, flake or short fibrous form. Such a haemostatic material is useful, for example, in reducing or stopping bleeding of a physiological target site in a person or animal, and can also be used to stem bleeding during medical procedures.

A wound management system can comprise a surgically acceptable adhesive disposed over a wound and a surgically acceptable film repositionably disposed over the surgically acceptable adhesive, and methods of managing a wound involving the same.

The present disclosure provides silicone-based biophotonic compositions and methods useful in phototherapy. In particular, the silicone-based biophotonic compositions of the present disclosure include a silicone phase and a surfactant phase, wherein the surfactant phase comprises at least one chromophore solubilized in a surfactant. The silicone-based biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and scarring, as well as various other skin disorders.

The present disclosure provides biophotonic compositions containing halogen ions and/or halogen salts and methods useful in phototherapy. In particular, the biophotonic compositions comprising halogen of the present disclosure include at least one chromophore; and halogens and/or halogen salts such KI, or KCl, or KBr, or CsBr, or MgBr.sub.2, or ZnBr.sub.2, or NaF, or NaCl, or NaBr, or I.sub.2, or I.sub.3.sup., or Br.sub.2, or Cl.sub.2. The biophotonic compositions and the methods of the present disclosure are useful for promoting tissue repair, wound healing, bone regeneration and skin rejuvenation, as well as treating oral diseases, microbial and viral infections, acne and various other skin disorders and various orphan diseases.

The present application provides a porous sintered multicomponent applicator nib and methods of making and using these nibs. The porous nibs are made from sintered plastic particles. These nibs are used with liquid applicators devices, medical devices, writing tools or cosmetic applicators to apply liquids containing high solids or pigments to surfaces such as metal, paper, skin, hair, tissue or a wound.

Provided is a method of preparing a superabsorbent polymer. According to the method of preparing the superabsorbent polymer of the present invention, provided is a superabsorbent polymer having improved physical properties, in which the superabsorbent polymer has improved absorption rate and liquid permeability without reduction in centrifuge retention capacity or absorbency under load.

Provided are a recombinant polypeptide in which a small leucine-rich proteoglycan mimetic sequence is attached to a terminal of a mussel adhesive protein, a composition for wound healing including the same, a bioadhesive material, and a preparation method thereof. According to the present disclosure, the recombinant polypeptide in which the small leucine-rich proteoglycan mimetic sequence is attached to the terminal of the mussel adhesive protein has an excellent epidermal regeneration effect in which the wound site is uniformly restored by promoting rapid wound healing at the wound site when being applied to the wound site and inducing formation of collagens which are arranged and concentrated at the wound site, and thus can be usefully used as various drugs, cosmetics, and quasi-drugs.

A family of silicone rubbers (e.g., polydimethylsiloxane) carrying one or more cyanoacrylate groups and their methods of production are provided. These silicone rubbers endowed with cyanoacrylate groups are useful in a variety of wound care applications, including wound closures, adhesives, sealants and skin protectors. The silicone rubber moiety provides oxygen and moisture permeability (i.e., breathability), biocompatibility, optical transparency, and good mechanical properties, while the cyanoacrylate group imparts instantaneous adhesion/attachment to living tissues such as skin on par with that of contemporary cyanoacrylate-based wound care products.