Novel compositions for treating wounds and promoting the healing thereof are described, including composition containing novel combinations of a carrier and recombinant platelet derived grown factor having fewer isoforms and enhanced biostability. Methods of treating wounds with novel therapeutic composition using dosing procedures leading to effective results with a minimal number of treatment applications are also described.

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

A system that includes a biocompatible polymeric matrix and a separately-stored fluid for improving delivery of a therapeutic gas to an area beneath a surface of intact skin or a wound site is provided. The system can preserve the therapeutic gas in the matrix such that its concentration remains generally constant until the system is ready for use, at which time the separately-stored fluid can be added or exposed to the matrix to activate the matrix and thus increase the permeability of the biocompatible polymeric matrix to the therapeutic gas, thus facilitating delivery of the therapeutic gas for the purpose of the treatment of wounds and intact skin is provided. A method of using the, as well as a deactivated matrix and its method of use for delivery of a therapeutic gas, are also provided.

Embodiments of the disclosure relate to devices (e.g., patches, plugs, beams, plates, screws, rods, granules, spacers, cages, discs, tape devices, or other shape determined by the geometry or anatomy of the site of application) and methods of use thereof.

A tissue-derived hydrogel, as well as methods of making and using such hydrogels, are provided.

Nanoparticle composites comprised of a metal oxide and ions of a metallic element included within a crystal lattice of said metal oxide are disclosed. Process of preparing the nanoparticle composites per se and incorporated in or on a substrate are also disclosed. Uses of the nanoparticle composites and of substrates incorporating same, particularly for reducing a formation of a load of a microorganism or of a biofilm, are also disclosed.

Provided herein is a antimicrobial sorption composition containing pyrogenic silica and serrathiopeptidase useful for the treatment of wounds such as festering wounds, necrotic wounds, exudative wounds, or wounds with inflammatory infiltration.

Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.

Described herein are compositions of collagen and micronized placental tissue components, methods for producing the same and methods for using the same for wound healing, repairing damaged tendons, cosmetic applications and covering biocompatible materials and/or devices.

Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work