Embodiments of the disclosure may include a pressure sensitive hydrogel composition. The composition may include a liquid solvent, a polymer, and an acid gas. The composition may be capable of having a fluid phase in which the acid gas is dissolved in the solvent and the polymer is dissolved in the solvent, and the composition may be capable of having a gel phase in which the acid gas is not dissolved in the liquid solvent and the polymer is precipitated out of the solvent. The composition may also include a chemical compound or a pharmaceutical agent that can be released after the composition is delivered to a target tissue region.

A chemically strengthened bioactive glass-ceramic composition as defined herein. Also disclosed are methods of making and using the disclosed compositions.

Provided is a bone-regeneration material comprising biodegradable fibers and exhibiting antimicrobial properties at an early stage following surgery, A method for producing a bone-regeneration material having antimicrobial properties and comprising biodegradable fibers, wherein the bone-regeneration material is produced by a step in which the biodegradable fibers are immersed in an inositol phosphate solution, then subsequently immersed in a solution containing silver ions, the biodegradable fibers have an outer diameter of 10-100 m, contain at least 30 wt % or more of a biodegradable resin and 40 wt % or more of calcium compound particles, and some of the calcium compound particles are exposed on the surface of the biodegradable fibers.

Provided is a bone-regeneration material comprising biodegradable fibers and exhibiting antimicrobial properties at an early stage following surgery, A method for producing a bone-regeneration material having antimicrobial properties and comprising biodegradable fibers, wherein the bone-regeneration material is produced by a step in which the biodegradable fibers are immersed in an inositol phosphate solution, then subsequently immersed in a solution containing silver ions, the biodegradable fibers have an outer diameter of 10-100 m, contain at least 30 wt % or more of a biodegradable resin and 40 wt % or more of calcium compound particles, and some of the calcium compound particles are exposed on the surface of the biodegradable fibers.

An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects, a method of preparation thereof, and a method of inducing or promoting bone growth by treatment of a bone with an autologous bone graft substitute composition. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof; and a compression resistant matrix selected from the group consisting of a bone autograft, bone allograft, hydroxyapatite, tri-calcium phosphate, and combinations thereof. The autologous blood forms a coagulum gel comprising a fibrin-meshwork reinforced with the compression resistant matrix and containing the osteogenic bone morphogenetic protein which is released over a sustained period.

The invention relates to a joint implant for new tissue formation at a joint, wherein the joint implant (1) comprises a rod-shaped body with a base area (11), a cover area (12) and a sleeve area (13), wherein at least the cover area (12), in particular the entire rod-shaped body, of the joint implant (1) has a hydrophobic surface for facilitating chondrocyte differentiation of mesenchymal stem cells, and a thread structure (15) is at least partially formed on the sleeve area (13) of the joint implant (1).

A method of preparing a sterilized injectable hydrogel composition, including the steps: a) covalently crosslinking a glycosaminoglycan using a bi- or polyfunctional crosslinking agent to form a covalently crosslinked glycosaminoglycan, b) swelling the covalently crosslinked glycosaminoglycan in a solution including a divalent cation to form a hydrogel composition, and c) sterilizing the hydrogel composition by autoclaving to form a sterilized injectable hydrogel composition, and to sterilized injectable hydrogel compositions obtainable by such method.

An implantable mesh including demineralized bone fibers mechanically entangled into a biodegradable or permanent implantable mesh is provided. A method of preparing the implantable mesh is also provided. The method of preparing the implantable mesh includes mechanically entangling demineralized bone fibers with non-bone fibers to form the implantable mesh. The mechanical entanglement of the bone fibers into the implantable mesh is achieved by applying needle punching with barbed needles, spun lacing, entanglement with water jets or air jets or ultrasonic entanglement with ultrasonic waves. A method of implanting an implantable mesh at a target bone tissue site is also provided.

An implantable mesh including demineralized bone fibers mechanically entangled into a biodegradable or permanent implantable mesh is provided. A method of preparing the implantable mesh is also provided. The method of preparing the implantable mesh includes mechanically entangling demineralized bone fibers with non-bone fibers to form the implantable mesh. The mechanical entanglement of the bone fibers into the implantable mesh is achieved by applying needle punching with barbed needles, spun lacing, entanglement with water jets or air jets or ultrasonic entanglement with ultrasonic waves. A method of implanting an implantable mesh at a target bone tissue site is also provided.

An object is to produce a collagen vitrigel, which has a high film strength even without performing a crosslinking treatment, and is easily produced and processed industrially and mechanically, and is also easy to handle and is highly safe, from collagen, and a purified product thereof. In order to achieve the object, it is directed to a method for producing a collagen vitrigel characterized by gelling collagen with a gelling agent containing an inorganic carbonate and a compound selected from the group consisting of an inorganic chloride and an inorganic phosphate, subsequently vitrifying the obtained collagen gel, and further subjecting the vitrified collagen gel to a hydration treatment; a method for producing a purified collagen vitrigel characterized by desalting, equilibrating, and further drying the collagen vitrigel; and a collagen vitrigel and a purified collagen vitrigel obtained by these methods.