Disclosed are spheroidal hybrid biodegradable materials containing low dimensional manganese dioxide (MnO.sub.2) support structures and cells, methods of manufacture thereof, and methods of use thereof.

A skeletal-hole plug comprising a hardened bone cement, which has a circular or polygonal column, and the column is a porous hardened bone cement with a porosity of 30% to 90% by volume, which can be used to rapidly fill the skeletal holes resulted from the removal of bone screws, or from the removal of teeth, and to induce rapid growth of osteocytes in the skeletal holes.

A skeletal-hole plug comprising a hardened bone cement, which has a circular or polygonal column, and the column is a porous hardened bone cement with a porosity of 30% to 90% by volume, which can be used to rapidly fill the skeletal holes resulted from the removal of bone screws, or from the removal of teeth, and to induce rapid growth of osteocytes in the skeletal holes.

A solid solution for use in bone regeneration. The solid solution includes two divalent cations, wherein a first divalent cation is calcium ion (Ca.sup.2+) and a second divalent cation is selected from the group consisting of magnesium ion (Mg.sup.2+), zinc ion (Zn.sup.2+), barium ion (Ba.sup.2+) and strontium ion (Sr.sup.2+). The solid solution also includes at least one anion, and the at least one anion comprises one or more of sulfate (SO.sub.4.sup.2−), phosphate (PO.sub.4.sup.2−), carbonate (CO.sub.3.sup.2−), and silicate (SiO.sub.3.sup.2−).

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.

Methods and devices are provided for the use of thin-film cuffs on endovascular grafts. A method includes forming a fenestrated thin-film Nitinol sheet, expanding the fenestrated thin-film Nitinol sheet to expand the fenestrations, and attaching the expanded thin-film Nitinol sheet to a longitudinal end of a cover for an endovascular graft to form a cuff for the endovascular graft. The method may further include implanting the endovascular graft into a blood vessel. An endovascular graft may include a cover having a proximal and distal end, a proximal thin-film mesh cuff extending from the proximal end, and a distal thin-film mesh cuff extending form the distal end.

A method of producing a product inorganic compound including: immersing a raw material inorganic compound having a volume of 10.sup.−13 m.sup.3 or more in an electrolyte aqueous solution or an electrolyte suspension; exchanging anions in the raw material inorganic compound with anions in the electrolyte aqueous solution or the electrolyte suspension; cations in the raw material inorganic compound are exchanged with cations in the electrolyte aqueous solution or the electrolyte suspension; or including a component (that excludes water, hydrogen, and oxygen) in the electrolyte aqueous solution or the electrolyte suspension not included in the raw material inorganic compound in the raw material inorganic compound; and obtaining a product inorganic compound having a volume of 10.sup.−13 m.sup.3 or more from the raw material inorganic compound.

A method of producing a product inorganic compound including: immersing a raw material inorganic compound having a volume of 10.sup.−13 m.sup.3 or more in an electrolyte aqueous solution or an electrolyte suspension; exchanging anions in the raw material inorganic compound with anions in the electrolyte aqueous solution or the electrolyte suspension; cations in the raw material inorganic compound are exchanged with cations in the electrolyte aqueous solution or the electrolyte suspension; or including a component (that excludes water, hydrogen, and oxygen) in the electrolyte aqueous solution or the electrolyte suspension not included in the raw material inorganic compound in the raw material inorganic compound; and obtaining a product inorganic compound having a volume of 10.sup.−13 m.sup.3 or more from the raw material inorganic compound.

The present invention relates to the field of treatment of bone defects. The invention provides a composition for treatment of bone defects as well as methods for treatment of such defects.

An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.