A claw-shaped pedicle screw fastener for osteoporosis includes an inner screw plug and an outer screw; the outer screw includes an outer nut and an outer screw stem, a through hole is defined in and penetrates through the outer nut and the outer screw stem, the outer screw stem has a thread segment, a claw-shaped segment, and a conical segment that are provided on outside of the outer screw stem; the claw-shaped segment is made of deformable metal; the inner screw plug includes an inner nut and an inner screw stem, the inner screw stem is inserted into the through hole, and the inner screw stem is threadedly connected to the first inner thread and the second inner thread; the inner screw stem and the second inner thread are reverse thread screws relative to each other.

A claw-shaped pedicle screw fastener for osteoporosis includes an inner screw plug and an outer screw; the outer screw includes an outer nut and an outer screw stem, a through hole is defined in and penetrates through the outer nut and the outer screw stem, the outer screw stem has a thread segment, a claw-shaped segment, and a conical segment that are provided on outside of the outer screw stem; the claw-shaped segment is made of deformable metal; the inner screw plug includes an inner nut and an inner screw stem, the inner screw stem is inserted into the through hole, and the inner screw stem is threadedly connected to the first inner thread and the second inner thread; the inner screw stem and the second inner thread are reverse thread screws relative to each other.

Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.

Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.

Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulating T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death of T-cells in various settings, e.g., in vitro, ex vivo, or in vivo. Embodiments described herein further relate to pharmaceutical compositions, kits, and packages containing such scaffolds. Additional embodiments relate to methods for making the scaffolds, compositions, and kits/packages. Also described herein are methods for using the scaffolds, compositions, and/or kits in the diagnosis or therapy of diseases such as cancers, immunodeficiency disorders, and/or autoimmune disorders.

Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulating T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death of T-cells in various settings, e.g., in vitro, ex vivo, or in vivo. Embodiments described herein further relate to pharmaceutical compositions, kits, and packages containing such scaffolds. Additional embodiments relate to methods for making the scaffolds, compositions, and kits/packages. Also described herein are methods for using the scaffolds, compositions, and/or kits in the diagnosis or therapy of diseases such as cancers, immunodeficiency disorders, and/or autoimmune disorders.

The presently disclosed composition and methods are provided for an in situ forming nanofiber-hydrogel composite, which is formed using non-covalent binding schemes between the fiber surface and hydrogel-forming polymers. A method for healing a soft tissue defect can include applying the said composite material to a soft tissue defect.

The presently disclosed composition and methods are provided for an in situ forming nanofiber-hydrogel composite, which is formed using non-covalent binding schemes between the fiber surface and hydrogel-forming polymers. A method for healing a soft tissue defect can include applying the said composite material to a soft tissue defect.

The present invention relates to implantable hair which is characterized in that it is coated at least in an implantable section with a composition that comes into direct or indirect contact with the hair and contains at least one silk protein. The present invention is further concerned with methods of producing such an implantable hair and the cosmetic use thereof.

The present invention relates to implantable hair which is characterized in that it is coated at least in an implantable section with a composition that comes into direct or indirect contact with the hair and contains at least one silk protein. The present invention is further concerned with methods of producing such an implantable hair and the cosmetic use thereof.