Method of making a musculoskeletal tissue reconstruction implant by warp knitting an implant of a biodegradable polymeric material to form a porous matrix or scaffold having a tensile stiffness at least by 50% lower than the tensile stiffness of the musculoskeletal tissue the implant is configured to reconstruct.

A platform for creating engineered tissues includes a vascular tube that defines a vascular diameter and is configured to receive vascular system seed cells, a non vascular tube that defines a non-vascular tube diameter and is configured to receive organ system seed cells, and a barrier formed between the vascular tube and the non vascular tube.

Provided is a dental pretreatment material for dental tissue regeneration by use of dental pulp stem cells, particularly a dental pretreatment material effectively enabling dental tissue regeneration even by use of dental pulp stem cells of middle-aged or older individuals. The dental pretreatment material is characterized by comprising a serine protease, specifically trypsin. The dental pretreatment material comprising trypsin is used as an injection into a root canal before a root canal filling material comprising dental pulp stem cells and an extracellular matrix is inserted into the root canal as an attempt to regenerate a dental pulp and a dentin. The root canal filling material includes an ALK5 inhibitor, a CCR3 antagonist, or a CCL11 neutralizing antibody.

Provided is a dental pretreatment material for dental tissue regeneration by use of dental pulp stem cells, particularly a dental pretreatment material effectively enabling dental tissue regeneration even by use of dental pulp stem cells of middle-aged or older individuals. The dental pretreatment material is characterized by comprising a serine protease, specifically trypsin. The dental pretreatment material comprising trypsin is used as an injection into a root canal before a root canal filling material comprising dental pulp stem cells and an extracellular matrix is inserted into the root canal as an attempt to regenerate a dental pulp and a dentin. The root canal filling material includes an ALK5 inhibitor, a CCR3 antagonist, or a CCL11 neutralizing antibody.

An ophthalmological composition includes at least one viscoelastic polymer, wherein the composition comprises at least one thermoresponsive compound that in a predefined wavelength range undergoes a temperature-dependent discontinuous change in at least one physical property from a group color and transmittance. The disclosure further relates to such an ophthalmological composition wherein a temperature-dependent change in the at least one physical property is reversible and/or wherein the temperature-dependent change in the at least one physical property occurs within not more than 10 seconds after a predefined temperature threshold value has been exceeded.

One embodiment of the present invention provides a nonwoven fabric containing silk fibers in which an abs intensity ratio [abs (1650)/abs (1620)], which is a ratio of an intensity of a peak positioned in a vicinity of 1650 cm.sup.−1 [abs (1650)] in an infrared absorption spectrum to an intensity of a peak positioned in a vicinity of 1620 cm.sup.−1 [abs (1620)] in an infrared absorption spectrum, is larger than 0.65 and 1.90 or less, and a method for producing the nonwoven fabric containing silk fibers.

A tissue restoration composition in a colloidal phase, includes a copolymer in which a hydrophobic biocompatible polymer and a hydrophilic biocompatible polymer are polymerized and which is dispersed in water. The colloidal phase has increased viscosity by heating the copolymer dispersed in water. The colloidal phase has a viscosity, by the heating, of 20-200,000 cP.

A tissue restoration composition in a colloidal phase, includes a copolymer in which a hydrophobic biocompatible polymer and a hydrophilic biocompatible polymer are polymerized and which is dispersed in water. The colloidal phase has increased viscosity by heating the copolymer dispersed in water. The colloidal phase has a viscosity, by the heating, of 20-200,000 cP.

An improved composition for a thermoplastic elastomer that is used in a product that touches the skin. The thermoplastic elastomer contains a styrene block copolymer, a plasticizing oil, and CBD oil. The plasticizing oil and the CBD oil, in combination, comprise at least eighty percent of the thermoplastic elastomer by weight. The plasticizing oil and the CBD oil have the same, or similar, molecular weights. In that manner, the plasticizing oil and the CBD oil can form a homogenous mixture. The CBD oil saturates the thermoplastic elastomer and will slowly bloom out of the thermoplastic elastomer over time. The migration of the CBD oil brings the CBD oil to the exposed surfaces of the thermoplastic elastomer, therein enabling the CBD oil to be absorbed by the skin.

Disclosed are Self-Gelling materials and structures or materials or structures having one or more self-gelling components that overcome existing gel limitations due to hydrogel localization for medical applications by providing, for example, 1) microstructurally, or physically, anchored characteristics to help localize the gel, and the overall printed, or otherwise formed structure, giving structural form to the gel that allows the gel to be localized within the body, and even sutured in place, and mitigates gel migration and extends its residence time; 2) to provide an underlying 3D printed structure to help contain and support the gel after implantation; and more. Self-Gelling 3D printed structures may be further processed via milling to yield deconstructed scaffold micro-granules, with the composition and nano-/micro- structure of the original larger structure. Deconstructed scaffold micro-granules may be hydrated to form a micro-granule embedded gel network that can be injected, giving form to injectable gels.