A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

The present invention provides an apparatus adapted for ejection of material, e.g., saliva, from the mouth of a patient during a dental procedure. The apparatus has at least two distal openings such that material may be ejected simultaneously from at least two locations within the patient's mouth. The invention provides a suction apparatus having a proximal tube, which may couple with a standard waste container apparatus having a suction source.

A bioresorbable device (2901) for implantation at a treatment site in the body of a patient, for draining fluid from the treatment site or delivering fluid to the treatment site. The device has a bioresorbable resilient truss (2915, 2916) for holding two tissue surfaces spaced apart, thereby defining a channel into which fluid from the treatment site can drain or from which fluid can be delivered to the treatment site, and a port in fluid communication with the one or more channels. The port is connectable to a source of negative pressure or positive pressure.

The present invention provides an implantable medical product in a pouch structure, comprising an extracellular matrix (ECM) structure in sheet form. The pouch structure has an internal region and is configured to receive an electrical medical device therein. In particular, a larger pouch structure is designed to accommodate a medical device having a larger size, such as a subcutaneous implantable cardioverter-defibrillators (S-ICDs). In particular, lock-stitched seamed ECM sheets form a larger pouch structure. It is preferable that the stitches can securely hold the ECM sheets together by providing mechanical strength and durability to withstand the weight of the electronic medical device. The stitches securely hold the pouch structure together and does not fall apart during trimming or cutting of the pouch structure.

The invention relates to methods of differentiation, isolation, propagation, and storage of small colony variants (SCVs) of E. coli, preferably E. coli 83972 or E. coli HU2117, or modified or variant forms thereof, and methods for using the prepared SCV bacteria to establish probiotic biofilms in treated subjects and/or on treated medical devices.

Systems and methods for biofilm inoculation including a feeding tube having a distal end for placement in the gut of a patient, and a biofilm coated or otherwise provided on the distal end of the feeding tube for introducing the biofilm to the gut of the patient. In example embodiments, the biofilm can be colostrum, breast milk or one or more probiotics.

The present disclosure discloses a composite tubular material and a preparation method thereof. The tubular material is prepared from extracellular matrix and directionally arranged synthetic polymer fibers through compounding; the synthetic polymer fibers serve as an internal skeleton, a fiber diameter ranges from 1 m to 2000 m, a fiber angle ranges from 0 to 180, and a wall thickness ranges from 1 m to 1000 m; and extracellular matrix components are obtained from human or animal tissue through decellularization. According to the present disclosure, the tubular material with bioactivity and excellent mechanical properties can be prepared from the synthetic polymer and the natural material extracellular matrix through compounding; the synthetic polymer fibers with controllable fiber angle and diameter serve as the internal skeleton of the tubular material, and accordingly the tubular material has the mechanical properties of resistance to bending and squeezing.

This document provides methods and materials for treating a mammal (e.g., a human) having one or more stenotic blood vessels. For example, amnion coated balloons that can be used in balloon angioplasty are provided.

The present invention disclosed a process to coat the surface of flexible polymeric implant with biocompatible polymer such that the coating does not crack when the implant is subjected to mechanical forces such as tension, torsion or bending while retaining the inherent properties of the coated polymer.

The present invention relates to a composition for preventing or treating stenosis, in which the composition includes brown algae extract, and more particularly to a composition for preventing or treating stenosis, in which the composition includes brown algae-derived polyphenol as an active ingredient, thereby providing excellent prevention or treatment effect on stenosis including tracheal stenosis, glottic stenosis, vascular stenosis, and the like.