Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.

The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

An intravascular blood pump (P) comprises a catheter (5) and a pumping device (1) attached to a distal end (15) of the catheter (5). The blood pump (P) is advanced through a patient's blood vessel by means of the catheter (5). The catheter (5) has an elongate tubular body (10) and a porous three-dimensional structure (6) provided on at least a portion of the outer surface (8) of the catheter body (10) to promote adsorption of proteins and formation of an autologous graft (7) to prevent the catheter (5) from growing into the inner wall of the blood vessel. The porous three-dimensional structure (6) may be formed as a textile sleeve (6), preferably made of a warp knitted fabric.

A medical device includes a resin base including one or more than one material selected from a group consisted by an ethylene propylene resin containing fluorine, a styrene resin containing fluorine, an olefin resin containing fluorine, a vinyl chloride resin containing fluorine, a polyester resin containing fluorine, a polyurethane resin containing fluorine, and a nylon resin containing fluorine; an underlayer formed on the resin base, the underlayer including an oxazolidone ring; and an epoxy resin layer formed on the underlayer.

A latex or natural rubber composition or formulation, latex or rubber products made using the same, and methods of preparing a vulcanized rubber and latex or natural rubber products are disclosed. The composition/formulation includes latex or natural rubber, 0.1-5 phr of a vulcanization activator, and 0.5-10 phr of one or more accelerators and/or additional activators. At least one accelerator and/or additional activator is a nanocomposite zinc oxide. The method includes. mixing a source of the latex or rubber with a vulcanization activator and one or more nanocomposite zinc oxides in a tank or vessel to form a latex or rubber formulation, dipping or at least partially immersing one or more molds or formers in the latex or rubber formulation to form a latex or rubber coating thereon, and curing the latex or rubber coating to vulcanize the latex or rubber coating. The vulcanized latex product is strong and has antimicrobial properties.

A latex or natural rubber composition or formulation, latex or rubber products made using the same, and methods of preparing a vulcanized rubber and latex or natural rubber products are disclosed. The composition/formulation includes latex or natural rubber, 0.1-5 phr of a vulcanization activator, and 0.5-10 phr of one or more accelerators and/or additional activators. At least one accelerator and/or additional activator is a nanocomposite zinc oxide. The method includes. mixing a source of the latex or rubber with a vulcanization activator and one or more nanocomposite zinc oxides in a tank or vessel to form a latex or rubber formulation, dipping or at least partially immersing one or more molds or formers in the latex or rubber formulation to form a latex or rubber coating thereon, and curing the latex or rubber coating to vulcanize the latex or rubber coating. The vulcanized latex product is strong and has antimicrobial properties.

The improvement device provides an oral suction system for use with endo-tracheal tubes. The device provides alternative anti-infective components and a removable and/or disposable external sleeve, both for mitigation or elimination of risks for viral and/or bacterial contamination of the patient and healthcare professional.

The improvement device provides an oral suction system for use with endo-tracheal tubes. The device provides alternative anti-infective components and a removable and/or disposable external sleeve, both for mitigation or elimination of risks for viral and/or bacterial contamination of the patient and healthcare professional.

Compositions comprising a protein or isolated peptide, and methods using the same for preventing, dispersing or detaching a biofilm, are disclosed.

A ureteral catheter structure, comprising a catheter body (1). The catheter body (1) comprises a stepped braided tube (2), a bending tube (3), and a plastic catheter tip (14) which are spliced with each other. A first stainless steel outer tube (4) supports and connects the stepped braided tube (2) and the bending tube (3) at a splice therebetween, and a first PET heat-shrinkable film (5) is coated on the first stainless steel outer tube (4). A second stainless steel outer tube (6) supports and connects the bending tube (3) and the plastic catheter tip (14) at a position therebetween, and a second PET heat-shrinkable film (7) is coated on the second stainless steel outer tube (6). A traction wire (8) is provided within the catheter body (1), an end of the traction wire (8) being fixed on the bending tube (3), while the other end passing through the stepped braided tube (2). A heat-shrinkable sleeve (9) is provided outside the bending tube (3). An end of the ureteral catheter may be independently bent in multiple sections, thereby achieving a good detection effect, and solving the technical problem of instability when an end of the ureteral catheter is deflected.