A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material. A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material.

The invention relates to a composition comprising: (A) a propylene-based polymer which is a propylene homopolymer or a propylene copolymer consisting of at least 90 wt % of propylene monomer units and at most 10 wt % of ethylene monomer units and/or an α-olefin monomer units having 4 to 10 carbon atoms, (B) a terpolymer of propylene, an α-olefin having 4 to 10 carbon atoms and ethylene and (C) a copolymer of ethylene and an α-olefin having 4 to 10 carbon atoms, wherein the copolymer (C) has a density of at least 0.880 g/cm.sup.3, wherein the amount of the propylene-based polymer (A) is at least 60 wt % with respect to the total composition.

Catheter tubing comprises: an elongate body comprising a base thermoplastic polyurethane; and a compounded thermoplastic polyurethane co-extruded with the base thermoplastic polyurethane to provide a section of catheter tubing discrete from the elongate body, the compounded thermoplastic polyurethane comprising a thermoplastic polyurethane and a radiopaque material, wherein the catheter tubing comprises a first elastic modulus under first conditions prior to entry into a patient; and wherein when exposed to second conditions comprising two or more in vivo stimuli for a duration of time the catheter tubing comprises a second elastic modulus that is not more than fifty percent of the first modulus.

A medical shaft includes a shaft including at least one lumen extending in a longitudinal direction; a core member disposed in the lumen, the core member extending along the longitudinal direction; and a tubular member disposed on an outer side of the core member in a same lumen as a lumen in which the core member is disposed, the tubular member having a length, in the longitudinal direction, which is less than a length of the core member, wherein in the lumen, an area of a cross-section of the lumen on a plane perpendicular to the longitudinal direction in a portion in which the tubular member is disposed is greater than an area of a cross section of the lumen on a plane perpendicular to the longitudinal direction in a portion in which the tubular member is not disposed.

The present teachings provide a catheter shaft design and configuration for use in the delivering and deploying a medical device, and aspiration removal of occlusion. Specifically, one aspect of the present teachings provides a catheter shaft design having a four-layer construction, an ultra-thin inner layer, a first coil middle layer, and a second braid middle layer, and an outer jacket layer. The first coil middle layer of the catheter shaft is made of a flat wire with width to thickness ratio of at least 2:1. The outer jacket layer of the catheter shaft is made of three different material with a soft durometer forming the distal portion of the outer jacket, a medium durometer material forming the middle/transitional portion of the outer jacket, and a stronger durometer material forming the proximal portion of the outer jacket.

An anti-bacterial coating composition for use with a medical implant is disclosed. The anti-bacterial coating composition includes a bacteriophage cocktail that is encapsulated in beads that are embedded within a hydrogel. Also disclosed are kits containing the anti-bacterial coating composition as well as methods of producing and using the coating composition.

A method of manufacturing a catheter shaft includes extruding an inner polymeric layer having a main lumen and two or more side lumens spaced about the main lumen; forming an outer polymeric layer about the inner polymeric layer; and inserting at least one elongate member, such as a wire, through each side lumen of the inner polymeric layer. The side lumens are less than about ⅕ the size of the main lumen. The method may further include the step of forming a braided layer between the inner polymeric layer and the outer polymeric layer. In an alternate embodiment, the method includes co-extruding an inner polymeric layer and a multi-lumen layer, the multi-lumen layer having two or more side lumens; forming an outer polymeric layer about the multi-lumen layer; and inserting at least one elongate member through each side lumen. Catheter assemblies made according to the described methods are also disclosed.

A microcatheter comprising an inner layer, a strike layer and an outer layer and a braided skeleton located between the inner layer and the outer layer, wherein the inner layer is made of Polytetrafluoroethylene (PTFE) and has a thickness of 0.0015 inch or less, wherein the strike layer includes a polyether block amide and has a thickness of 0.001 inch or less, and wherein a distal portion of said outer layer is made of polycarbonate-based thermoplastic polyurethane having a shore of 90A or below.

A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

Solutions containing collagen monomers and saccharides inhibit the nucleation and growth of collagen fibrils. The solutions stabilize high concentrations of soluble collagen monomers, improving their incorporation into pre-existing tissues or collagen networks, thereby providing therapeutic applications of collagen for cosmetic treatments, wound healing, and injury repair involving damaged extracellular matrix. Pharmaceutical formulations, medical devices, and kits containing the solutions are provided.