The present invention relates to a method for preparation of a functionalized surface comprising the steps: a) coating of a carrier with a least one polymer selected from a polyanionic or polycationic polymer, b) addition of at least one compound to the coated carrier of step a), c) exposing the at least one polyanionic or polycationic polymer on the coated carrier of step b) to an organic solvent, resulting in compaction of the at least one polyanionic or polycationic polymer and thereby encapsulating the at least one compound, d) reversible cross-linking of the at least one polyanionic or polycationic polymer of step c) with at least one cross-linker; e) removal of the organic solvent. Furthermore, the invention relates to a functionalized surface, a functionalized surface for use in medicine and a method for releasing a compound ex vivo.

Medical articles formed from a polyurethane-based resin including a modifying oligomer provide enhanced properties. A modifying oligomer incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by a diisocyanate, a polyglycol, and a diol chain extender has at least one, preferably two, alcohol moieties (C—OH) and a functional moiety. Exemplary modifying oligomers are: a diol-containing perfluoropolyether incorporated into the backbone, a monofunctional polysiloxane (e.g., monodialcohol-terminated polydimethylsiloxane) incorporated as the side chain, and combinations thereof. Medical articles herein are self-lubricating and/or anti-fouling.

Medical articles formed from a polyurethane-based resin including a modifying oligomer provide enhanced properties. A modifying oligomer incorporated into a backbone, as a side chain, or both of the polyurethane-based resin formed by a diisocyanate, a polyglycol, and a diol chain extender has at least one, preferably two, alcohol moieties (C—OH) and a functional moiety. Exemplary modifying oligomers are: a diol-containing perfluoropolyether incorporated into the backbone, a monofunctional polysiloxane (e.g., monodialcohol-terminated polydimethylsiloxane) incorporated as the side chain, and combinations thereof. Medical articles herein are self-lubricating and/or anti-fouling.

The invention provides a packaged intermittent catheter, the intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and an amphiphilic lubricious additive, housed in a packaging container; and further comprising an aqueous solution in the packaging container; wherein the aqueous solution comprises at least one compound selected from the group comprising: a surfactant and/or poly (alkylene oxide) compound with a total concentration of at least 0.005 mmol/L; and a salt in a concentration of at least 5% w/v.

A method of producing a medical device having a substrate and a hydrophilic polymer layer, including the steps of: pretreating the substrate by placing the substrate in an alkali solution and heating the substrate at a temperature ranging from 50° C. to 100° C.; and heating a solution containing the pretreated substrate, a hydrophilic polymer having an acidic group and a hydroxyalkyl group, and an organic acid at a temperature ranging from 50° C. to 100° C. Provided is a simple method of producing a medical device imparted with hydrophilicity excellent in durability.

The invention provides an intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and further comprising an amphiphilic additive at and/or on an outer surface of the body, wherein one or both of the base polymer and the additive are independently cross-linked and/or the base polymer and additive are cross-linked with each other.

The invention provides an intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and further comprising an amphiphilic additive at and/or on an outer surface of the body, wherein one or both of the base polymer and the additive are independently cross-linked and/or the base polymer and additive are cross-linked with each other.

The invention provides an intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and a layer comprising a lubricious additive on or comprising a surface of the body, wherein the lubricious additive comprises an amphiphilic molecule.

The invention provides an intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and a layer comprising a lubricious additive on or comprising a surface of the body, wherein the lubricious additive comprises an amphiphilic molecule.

A method for making an insertable or implantable medical device including a lubricous coating on a silicone substrate includes treating the silicone substrate with an atmospheric plasma at about atmospheric pressure, the atmospheric plasma formed from a noble gas; applying a solution directly to the treated silicone substrate, the solution including a thermoplastic polyurethane; and heating the silicone substrate and the applied solution to form the lubricous coating on the silicone substrate.