A drug-loaded medical device, a preparation method therefor, a drug balloon and a method of preparing a drug coating are disclosed. The medical device or the drug balloon is provided on a surface thereof with a drug coating including a stabilizer and a drug. The stabilizer includes an amphiphilic triblock polymer with hydrophilic segments at both terminals, and the drug coating forms a nano-drug particle suspension in a water-soluble environment. In this way, the prepared nano-drug coating has high drug loading and can deliver the drug in a desirable way. In particular, when it comes into contact with water, the drug can be restored to the original nano size, almost without any particle size increase. This not only avoids the risk of embolism caused by granules, but also enables higher device safety, increased drug uptake and improved therapeutic effects.

The presently disclosed embodiments relate to devices and methods for efficiently removing the nitrogen dioxide (NO.sub.2) from a gas stream while enhancing the concentration of nitric oxide (NO) in the gas stream without making any reaction byproduct that will adversely influence a respiratory treatment. The devices and methods for nitric oxide (NO) generation and nitrogen dioxide (NO.sub.2) removal or scrubbing can be embedded into other therapeutic devices or used alone.

The presently disclosed embodiments relate to devices and methods for efficiently removing the nitrogen dioxide (NO.sub.2) from a gas stream while enhancing the concentration of nitric oxide (NO) in the gas stream without making any reaction byproduct that will adversely influence a respiratory treatment. The devices and methods for nitric oxide (NO) generation and nitrogen dioxide (NO.sub.2) removal or scrubbing can be embedded into other therapeutic devices or used alone.

A drug-loaded implanted medical device (10) and a preparation method therefor. The drug-loaded implanted medical device (10) comprises a device body (100), a hydrophilic coating layer (200) loaded on the device body (100), and crystalline drug particles (300) loaded on the hydrophilic coating layer (200). The hydrophilic coating layer (200) comprises a graft polymer containing a photo-crosslinked group. The medical device (10) uses a hydrophilic coating layer (200) as a carrier, effectively avoiding the risk of embolism, encouraging the crystalline drug particles to fall off, and helping to achieve a target tissue concentration. The invention can also effectively increase the anchoring effect between the carrier and the device, and reduce toxicity.

A composite electrode intracardiac defibrillation catheter includes a first electrode group including at least two first electrodes for detecting an electrophysiological electrical signal of a site or a cell group in a heart chamber, and a second electrode group including at least one second electrode located between an adjacent pair of the at least two first electrodes for causing an electric current by a high-voltage defibrillation electric shock for defibrillation to flow in a contact site in the heart chamber or a contact site in a vein, and a conductive length of a surface of the at least one second electrode in a longitudinal direction of the composite electrode intracardiac defibrillation catheter is longer than a conductive length of each of the at least two first electrodes.

An object is to provide a zwitterionic compound having an excellent protein adsorption inhibitory effect. The zwitterionic compound is a polymer comprising a unit represented by the following formula (1):

##STR00001##

wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is OH or O.sup.−, X.sup.1 is —O— or —N(Q.sup.1)-, Q.sup.1 is a hydrogen atom or a C.sub.1-6 alkyl group, m is an integer of 1 to 12, and n is an integer of 1 to 4.

Multifunctional crosslinkers are a reaction product between a polyaziridine compound and two or more functionalized benzophenones. The polyaziridine compound is linked to the functionalized benzophenones through two or more reacted aziridine groups. Coating compositions, comprising: a polymer, and multifunctional crosslinkers. Coated medical devices, comprise a lubricious coating bonded adjacent to an exterior surface of the medical device. The lubricious coating is prepared by UV-curing a coating composition, wherein the coating composition comprises: a water/isopropyl alcohol (IPA) soluble polymer and/or a UV-curable polymer, and a water/IPA soluble multifunctional crosslinker.

Multifunctional crosslinkers are a reaction product between a polyaziridine compound and two or more functionalized benzophenones. The polyaziridine compound is linked to the functionalized benzophenones through two or more reacted aziridine groups. Coating compositions, comprising: a polymer, and multifunctional crosslinkers. Coated medical devices, comprise a lubricious coating bonded adjacent to an exterior surface of the medical device. The lubricious coating is prepared by UV-curing a coating composition, wherein the coating composition comprises: a water/isopropyl alcohol (IPA) soluble polymer and/or a UV-curable polymer, and a water/IPA soluble multifunctional crosslinker.

The present invention relates to a tube member having excellent local bending properties that is capable of being freely bent only on a given region thereof at a working temperature, thereby enabling the bending angle thereof to be freely adjusted by a user, and a method for manufacturing the tube member. According to the present invention, the tube member having excellent local bending properties, which is made of an alloy, may include a first region and a second region having different alloy structures from each other. According to the present invention, the first region may be in a cold-worked state or have an austenite phase at a given working temperature, and the second region may have a martensite phase at the given working temperature and a yield stress value lower than a yield stress value of the first region.

The present invention is an inflatable balloon which is enclosed by an expandable cover which becomes increasingly porous/permeable during expansion. The balloon is coated or enclosed with a matrix which contains a pharmaceutically active agent. During expansion of the balloon, the pharmaceutically active agent is released or extruded through the expandable cover into a body cavity such as an artery or vein. The present invention also provides for a method of treating a disease or condition by delivering the inflatable balloon to a particular body cavity.