Aspects herein relate to apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a two-part fluid applicator defining a central channel, the two-part fluid applicator can include a first part having a first degree of flexibility; and a second part having a second degree of flexibility. The system can further include a fluid supply conduit in fluid communication with the fluid applicator; and a fluid supply reservoir in fluid communication with the fluid supply conduit. Other embodiments are also included herein.

A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.

A tissue repair patch having an outer side and an inner side is described. The tissue repair patch includes a structural component comprising collagen and/or chorion and a regenerative component comprising amniotic tissue. Methods of tissue repair using the tissue repair patch are also described.

A bioartificial device, such as a bioartificial pancreas, for implantation in a patient's vascular system. The bioartificial pancreas includes a scaffold adapted to engage an interior wall of a blood vessel, a cellular complex support by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising one or more pockets bordered by thin film; and cellular complex comprising pancreatic islets disposed in the one or more pockets, the thin film being adapted to permit oxygen and glucose to diffuse from flowing blood into the one or more pockets at a rate sufficient to support the viability of the islets. The invention also includes methods of making and using a bioartificial pancreas.

A bioartificial device, such as a bioartificial pancreas, for implantation in a patient's vascular system. The bioartificial pancreas includes a scaffold adapted to engage an interior wall of a blood vessel, a cellular complex support by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising one or more pockets bordered by thin film; and cellular complex comprising pancreatic islets disposed in the one or more pockets, the thin film being adapted to permit oxygen and glucose to diffuse from flowing blood into the one or more pockets at a rate sufficient to support the viability of the islets. The invention also includes methods of making and using a bioartificial pancreas.

Compliance control stitch patterns sewn or embroidered into biotextile or medical textile substrates impart reinforcing strength, and stretch resistance and control into such substrates. Compliance control stitch patterns may be customizable to particular patients, substrate implantation sites, particular degenerative or diseased conditions, or desired time frames. Substrates having compliance control stitch patterns sewn or embroidered into them may be used in tissue repair or tissue reconstruction applications.

The present invention disclosed a process to coat the surface of flexible polymeric implant with biocompatible polymer such that the coating does not crack when the implant is subjected to mechanical forces such as tension, torsion or bending while retaining the inherent properties of the coated polymer.

The polymer film serves for the embedding of a medical technology product to be implanted in a human organism. The polymer film includes a polymer of natural origin being biodegradable and absorbable by the human body. The polymer film has a polymer content. The polymer film further includes two antimicrobial active ingredients having a different mechanism of action and the polymer film has a total active-ingredient content. The ratio of the total active-ingredient content to the polymer content is at least 15%. The polymer content is greater than the total active-ingredient content. The polymer film is bendable and modulable and uninterrupted. The polymer forms a polymer matrix in which the antimicrobial active ingredients are embedded in a homogeneously distributed manner. The polymer film has, for each of the antimicrobial active ingredients, an individual active-ingredient content deviating from one another by at most 20%.

The invention relates to a stent for placement at an aortic annulus that is expandable from an undeployed state to a deployed state comprising a stent frame having rows of cells with a proximal section and a distal section at a longitudinal axis of the stent, the stent frame being formed by a plurality of arms, the arms being connected to one another at connection points, and wherein the plurality of arms forms a plurality of diamond-shaped stent cells, in particular the rows of cells, formed of vertices at said connection points between the arms, a dry valve made out bovine pericardium arranged at least at the distal section of the stent with the dry bovine pericardium being configured to be rehydrated with a solution, a skirt surrounding the dry valve and comprising at least one of bovine pericardium and polyester, and one or more eyelets arranged at a distal end of some of the arms, with the eyelets being configured to fix the valve to the stent frame.

The invention relates to a self-expandable stent, especially a pulmonary stent, with a proximal section, a middle section and a distal section arranged at a longitudinal axis of the stent, the stent having a dry valve made of bovine pericardium arranged at the middle section thereof, a skirt surrounding the dry valve at least at the middle section and made of one of bovine pericardium and polyester, wherein the stent further comprises eyelets arranged at a distal end at the distal section and/or a proximal end at the proximal section for fixing the stent at an artery, and wherein the stent comprises a frame composed of a plurality of arms forming the proximal, the middle and the distal section with the sections being interconnected, and the stent comprising a fixture area at the middle section of the frame with the arms being arranged in parallel to each other at the fixture area and the middle section comprising one or more fixture openings at said fixture area for fixing the valve at the frame. The invention further relates to A delivery device for delivering a self-expandable stent according to claims 1 to 14, the delivery device comprising a flush port, a main body part for holding, inflating and/or releasing the stent, and an actuation mechanism for moving the stent to a delivery site, and/or wherein the actuation mechanism has a torque control and can rotate the stent about an axis of the main body, and/or the delivery device having a knob or the like at the actuation mechanism, with the knob in particular being able to be rotated about an axis of rotation of the actuation mechanism.