A bioartificial device, such as a bioartificial pancreas, for implantation in a patient's vascular system. The bioartificial pancreas includes a scaffold adapted to engage an interior wall of a blood vessel, a cellular complex support by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising one or more pockets bordered by thin film; and cellular complex comprising pancreatic islets disposed in the one or more pockets, the thin film being adapted to permit oxygen and glucose to diffuse from flowing blood into the one or more pockets at a rate sufficient to support the viability of the islets. The invention also includes methods of making and using a bioartificial pancreas.

A device for administration of substances onto an epicardial surface of a heart includes a frame structure for at least partially encircling a circumference of the heart which is able to assume shaping, positioning, guiding and stabilizing functions. The frame structure may be coupled to a heart-shaped sleeve. A substance carrier for accommodating the substances to be administered may be coupled to the device.

Tissue prostheses having a base structure and a physiological sensor system. The tissue prostheses are adapted and configured to induce remodeling of damaged tissue and regeneration of new tissue and concurrently detect and monitor physiological characteristics when implanted in the subject.

Methods for producing crosslinked tissue matrices, crosslinked tissue matrices produced by such methods, as well as tissue products comprising such tissue matrices are disclosed. The methods comprise (1) dehydrating a collagen-containing tissue matrix to form a dehydrated collagen-containing tissue matrix; and (2) irradiating the dehydrated collagen-containing tissue matrix such that at least a portion of the dehydrated collagen-containing tissue matrix is crosslinked.

The invention relates to a device for closing a vein juncture in the treatment of varicose veins including a catheter which can be inserted into a venous system and at the distal end of which an expandable balloon is arranged, a covering which is arranged circumferentially on the balloon and can be expanded by means of said balloon, wherein the proximal covering end is designed to be open, and at least one adhesion agent for acting on the expanded covering such that it adheres to a vein wall in order to close the vein juncture.

A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more restoration agents, wherein the one or more restoration agents are suitable for a targeting position and are coated on the surface of the bioabsorbable stent. A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more bioabsorbable films, wherein the bioabsorbable films are loaded with restoration agents and/or drugs suitable for a targeting position.

Hygienic Hydrophilic coatings, hydrophilic coating formulations and wetting fluids that include an anti-infective agent.

Hygienic Hydrophilic coatings, hydrophilic coating formulations and wetting fluids that include an anti-infective agent.

A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.

The invention relates generally to the fields of biology and health sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in amniotic membrane tissue and umbilical cord tissue preparations.