Provided are methods and compositions for inducing periapical tissue regeneration and repair.

An orthodontic adhesive includes components capable of allowing easy debonding of an orthodontic device from a patient's tooth. The adhesive includes an engineered marine mussel protein. The adhesive may include at least one photocleavable moiety. The adhesive is applied in one or more individual layers. One of the components of the adhesive is capable of binding to a tooth and the other component may be capable of binding to an orthodontic device. A method of adhering an orthodontic device to a tooth includes applying a layer of an orthodontic adhesive to either the tooth or the orthodontic device or the tooth and the orthodontic device and affixing the orthodontic device to the tooth with the orthodontic adhesive situated between the tooth and the orthodontic device. The engineered marine mussel protein includes one or more catechol moieties or one or more derivatives of a catechol moiety.

The invention relates to a method for producing a storable molded body made of bacterial cellulose and a molded body produced according to the method. A preferred method includes providing a molded body made of bacterial cellulose. Optionally, mechanically pressing the entire molded body or parts of the molded body at temperatures in the range of 10° C. to 100° C. and pressures in the range of 0.01 to 1 MPa for a pressing time of 10-200 min. Treating the molded body with a solution of 20% by weight to 50% by weight of glycerol and 50% by weight to 80% by weight of a C1-C3-alcohol/water mixture. Drying the treated molded body.

A method for preparing non-free radical photo-crosslinked hydrogels includes: dissolving component A that is a polymer derivative modified with o-nitrobenzyl phototrigger in a biocompatible medium to obtain solution A; dissolving component B that is a polymer derivative containing hydrazide, hydroxylamine or primary amine in a biocompatible medium to obtain solution B; mixing solution A and solution B to obtain a precursor solution of hydrogel; under light irradiation, crosslinking aldehyde generated from the o-nitrobenzyl with the hydrazine, hydroxylamine or primary amine to obtain a hydrogel by forming hydrazone, oxime or schiff base, respectively. A kit for preparation and application of the hydrogel in tissue repair, beauty therapy, and cells, proteins or drugs carriers is also described. The method or kit can achieve in situ photo-gelling on tissue surface or in situ forming thin gel on wounds in clinical treatment of wounds.

An inflatable medical article that includes: a polyester-containing layer including a fabric layer that includes at least one nonwoven web of fibers including an aliphatic polyester, wherein at least a portion of the aliphatic polyester is exposed at the surface of the fibers; a polyolefin-containing layer including a polyolefin film, a nonwoven web including polyolefin fibers, or a combination thereof; a tie layer bonding the polyester-containing layer to the polyolefin-containing layer; an optional sheet; and at least one inflatable chamber formed between the polyolefin-containing layer and the tie layer, or between the polyester-containing layer and the tie layer, or between the polyolefin-containing layer and the optional sheet (when the sheet is present).

Provided is a dental cord using a nanofiber multiple yarn having a large specific surface area and a large number of three-dimensional pores, thereby effectively impregnating a drug such as a hemostatic agent, and a method of manufacturing the dental cord. The dental cord includes: a nanofiber multiple yarn which is obtained by plying and twisting at least two nanofiber tape yarns and which is impregnated with a drug, wherein the at least two nanofiber tape yarns are integrated by nanofibers made of fiber moldability polymer materials and having an average diameter of less than 1 μm, to thus be formed of a nanofiber web having three-dimensional micropores.

Disclosed are hydrogels polymerized with a free radical scavenger, for example a spin trap. The hydrogels are biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) spin trap end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the free radical scavenging aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.

Medical constructs with collagen fibers and gelatin and related collagen fibers. The collagen fibers can be derived from extruded soluble dermal collagen and can include a gelatin film attached to the at least one collagen fiber. The gelatin film can include one or more minerals and has a gelatin concentration of between about 0.1% to about 40% weight per volume.

Methods of forming and/or manufacturing polymeric stents are disclosed. Polymeric stents are also disclosed.

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.