In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site. In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.

A syringe includes a syringe body, a syringe cone having a distal opening, and a connection arranged in the region of the syringe cone, wherein the syringe body includes a first material and the connection includes a second material, and wherein the first material is different from the second material and the second material is a softer material than the first material.

According to an example aspect of the present invention, there is provided an auxetic structure, comprising or consisting of cellulosic material, preferably comprising nanostructured or microstructured cellulose on at least one of its surfaces or consisting of nanostructured or microstructured cellulose and optionally other cellulosic material.

The invention describes method for delivering and positioning radio-isotopes. The method uses encapsulating free flowing medicament into a leak proof vehicle and positioning the vehicle into the body. Also provided is a system for delivering and positioning radio-isotopes into the body, the system comprising fluid radio-isotope encapsulated in a leak proof material and/or absorbable material.

The invention describes method for delivering and positioning radio-isotopes. The method uses encapsulating free flowing medicament into a leak proof vehicle and positioning the vehicle into the body. Also provided is a system for delivering and positioning radio-isotopes into the body, the system comprising fluid radio-isotope encapsulated in a leak proof material and/or absorbable material.

A hydrogel 1 having a laminate structure of layer A 10 and layer B 20, wherein layer A 10 contains a monomer-derived component, water, a humectant, a water-insoluble polymer having tackiness and an amphiphilic polymer, the water-insoluble polymer is contained in a proportion of 3 to 20 wt % based on a total amount of layer A, and the amphiphilic polymer is a polyvinyl alcohol having a saponification degree of 50 to 75% and is contained in a proportion of 0.05 to 5 wt % based on the total amount of layer A; layer B 20 contains a monomer-derived component, water and a humectant and is substantially free of a water-insoluble polymer having tackiness and a polyvinyl alcohol; and an amount of the water based on a total amount of layer B is the amount of water based on the total amount of layer A±10 wt %.

Treatment of palatal defects is accomplished through devices that have controlled start time. The devices expand directionally to provide appropriate levels of stress and strain to a target tissue to promote tissue growth over the course of days or weeks, even as the defect repairs itself.

A cardiovascular fibrous implant for rebuilding elastin and the use of such an implant, wherein the implant is comprised of fibers forming a network, and wherein the fibers comprised in said network have a fiber diameter of 150 μm or less.

A biocompatible adhesive is disclosed. The biocompatible adhesive includes a substrate and a plurality of micro-scale elements extending from a surface of the substrate having a length selected to puncture a layer of a target tissue or target material. At least some of the micro-scale elements include at least one protrusion dimensioned to anchor the biocompatible adhesive to the target tissue or target material. A medical device assembly is also disclosed. The medical device assembly includes the biocompatible adhesive coupled to a surface of a component of the medical device assembly and positioned to attach the medical device assembly to the target tissue or target material. A method of facilitating attachment of a medical device assembly to a target tissue is also disclosed. A method of facilitating treatment of a wound is also disclosed.

Described herein is a three-dimensional platform delivery technology including a polymeric material.