The present invention provides an anchor system for musculoskeletal applications, e.g., for anchoring tendons or ligaments to bone or anchoring two or more bone sections. The anchor system comprises a substantially solid pre-manufactured distal portion (i.e., anchor component) and a settable, biodegradable composite. The biodegradable composite is flowable at the time of delivery and is introduced into the fixation site before or after the anchor component. Both the anchor component and the biodegradable composite may be manufactured from citrate-based polymers.

Reinforced biocomposite materials. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof.

A biocompatible, resorbable biphasic collagen membrane having a first area of relatively higher tensile strength and stiffness and lower porosity and a second area of relatively lower tensile strength and stiffness and higher porosity, and a method of manufacturing the such a membrane.

A biocompatible, resorbable biphasic collagen membrane having a first area of relatively higher tensile strength and stiffness and lower porosity and a second area of relatively lower tensile strength and stiffness and higher porosity, and a method of manufacturing the such a membrane.

Described are transdermal drug delivery compositions comprising amphetamine, methods of making transdermal drug delivery compositions comprising amphetamine, and therapeutic methods of using them. In specific embodiments, the compositions are free of components with moieties that are reactive with amphetamine. In specific embodiments, the compositions are manufactured using solvents free of components with moieties that are reactive with amphetamine. Therapeutic methods using the compositions also are described.

The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

A method of reducing surgical site infection (SSI), using a coated medical device having a tissue penetrating surface and an abradable coating on the medical device comprising at least one antimicrobial agent in the coating.

The present invention concerns a bio-resorbable prosthesis (1, 1′) for organs with lumens, as blood vessels and the like, comprising at least one bio-absorbable material layer (2), intended to be arranged in contact with said lumen organ when said prosthesis (1, 1′) is implanted, and at least one auxetic material layer (3), arranged in contact with said at least one bio-absorbable material layer (2).

The present invention also concerns a method for the production of a bio-absorbable prosthesis (1, 1′).

The disclosure relates to a simulated tissue useful as a surgical training aid, the simulated tissue including at least the following: (a) a skin layer, (b) a fat layer, (c) a muscle layer, (d) a first mesh, (e) an interstitial layer, (f) a second mesh, (g) a structural layer incorporating one or more anatomical components, and (h) a base layer. Methods for constructing the simulated tissue are also disclosed. The simulated tissues described herein can be used as a soft tissue surgical task trainer for numerous surgical procedures.