A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.

Polymeric based closed cell foams, such as shape memory polymer foams, contain bubbles. Making these bubbles continuous is called reticulation. Disclosed are embodiments of a device and method to controllably reticulate polymer-based closed cell foams by puncturing the membranes of these polymer-based closed cell foams.

In an embodiment, a method of producing a radiopaque stent graft is provided. The method may include functionalizing a surface of a coating layer of a stent graft to produce a functionalized surface; disposing a tie layer over the functionalized exterior surface of the stent graft; disposing an adherent layer over the tie layer; etching a slot into the adherent layer; functionalizing the slot; and positioning a radiopaque marker in the slot to produce a filled slot and thereby produce the radiopaque stent graft.

Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.

Implantable medical devices, such as embolic devices and blood flow filters are disclosed, the devices being made at least partially out of a platinum-tungsten alloy, wherein a percentage of tungsten in the alloy is equal to or greater than about 10% of the alloy by weight.

Implantable medical devices, such as embolic devices and blood flow filters are disclosed, the devices being made at least partially out of a platinum-tungsten alloy, wherein a percentage of tungsten in the alloy is equal to or greater than about 10% of the alloy by weight.

Implantable scaffolds that treat solid tumors and escape variants and that provide effective vaccinations against cancer recurrence are described. The scaffolds include genetically-reprogrammed lymphocytes and a lymphocyte-activating moiety.

Disclosed is a surgical staple for a combination energy stapler surgical instrument. The staple includes a crown defining a base, first and second deformable legs extending from the each end of the base and an electrically insulative material disposed on at least a portion of the base.

Disclosed is a surgical staple for a combination energy stapler surgical instrument. The staple includes a crown defining a base, first and second deformable legs extending from the each end of the base and an electrically insulative material disposed on at least a portion of the base.

An object of the present invention is to provide a Zr—Nb-based alloy material as a low-magnetic susceptibility alloy having a high corrosion resistance while maintaining a magnetic susceptibility equivalent to or less than the magnetic susceptibility of the biological alloy of the related art, a method for manufacturing the alloy material, and a Zr—Nb-based alloy product. The Zr—Nb-based alloy material according to the present invention includes, as a chemical composition, 3% by mass or more and 18% by mass or less of Nb, 12% by mass or less of Ti, 6% by mass or less of Cr, 6% by mass or less of Cu, 5% by mass or less of Bi, and a remainder consisting of Zr and unavoidable impurities, in which isothermal ω phase particles are dispersed and precipitated in β phase crystal grains of a parent phase.