The invention is related to a method for creating coating for medical implantable devices placed inside the recipient's body and having at least one surface contacting with blood, in particular, on blood vessel prostheses made of a polymeric material (polyethylene terephthalate), in order to activate the endothelization process and prevent thrombosis. For this purpose, the specified method is characterized by the alternation of stages of ion etching with spray coating.

The proposed method allows to create a discontinuous coating on a polymer vascular prosthesis made of polyethylene terephthalate, characterized by low thrombogenicity.

The invention is related to a method for creating coating for medical implantable devices placed inside the recipient's body and having at least one surface contacting with blood, in particular, on blood vessel prostheses made of a polymeric material (polyethylene terephthalate), in order to activate the endothelization process and prevent thrombosis. For this purpose, the specified method is characterized by the alternation of stages of ion etching with spray coating.

The proposed method allows to create a discontinuous coating on a polymer vascular prosthesis made of polyethylene terephthalate, characterized by low thrombogenicity.

An implantable apparatus, including at least one corrodible zinc-containing portion, where a content range of zinc in the at least one zinc-containing portion is [30, 50) wt. % and zinc in the zinc-containing portion is an amorphous structure, or a content range of zinc in the at least one zinc-containing portion is [50, 70] wt. %, and a microscopic structure of zinc in the zinc-containing portion is at least one of an amorphous structure, a non-equiaxed structure, an ultrafine-grained structure, or an equiaxed structure with a grain size number of 7 to 14, or a content range of zinc in the at least one zinc-containing portion is (70, 100] wt. % and a microscopic structure of zinc in the zinc-containing portion is at least one of a non-equiaxed structure, an ultrafine-grained structure, or an equiaxed structure with a grain size number of 7 to 14.

Provided herein are magnesium-based sponges and foams and methods for surface modification to enhance bioactivity. The magnesium-based sponges and foams may be useful as tissue or bone grafts which promote cellular adhesion and osseointegration and conduction, as well as various other biological functions including, for example, antibacterial properties, hydrophobicity or hydrophilicity and the ability to modulate immune response. The described sponges and foams have precise mechanical properties which are specifically designed for enhanced integration with surrounding tissue. The described magnesium-based materials are bioresorbable, allowing for the gradual, safe absorption of the material when exposed to bodily fluids.

The present disclosure relates to a catheter lock solution which instills into the lumen of the catheter and helps to maintain catheter patency when the catheter is not used for treatment of a patient. In particular, the present invention and its embodiments relate to a use of sodium bicarbonate solution as a catheter lock solution.

The present invention discloses a preparation method of a titanium nail capable of loading a drug. The titanium nail capable of loading a drug includes a titanium nail body capable of loading a drug, and a microporous ceramic layer capable of loading a drug arranged on the surface of the titanium nail body. The steps of the method include: pretreating the surface of the titanium nail body, preparing a microporous mould for hyaluronic acid-alginic acid microspheres, preparing a titanium sol solution, coating film, pore-forming and calcining. It fails to generate the exfoliations and the wear debris to prevent the human body from wear debris disease and reaction to a foreign body. Moreover, various drugs such as the antibacterial drugs, and the drugs for promoting the healing etc. can be loaded, targeted and slow-released, which is good for medical usage.

Described is a device for preventing thrombosis formation on surfaces of a blood contact device. The device may first non-invasively scan the blood contact device and determines the highest risk thrombosis points. The device then, preferably starting with the highest risk location, delivers a succession of harmonic vibration signals or electromagnetic signals non-invasively so as to prevent clot formation at each stagnation high risk point of the blood contact device (e.g., harmonic resonance). This resonant vibration calibration tuning information is stored in an associated microprocessor. The signals are then delivered, based upon the stored information, in a loop from the signal generator, usually on a belt outside the patient, to each stagnation point in sequence from highest risk of thrombosis to lowest; again and again repeated. By delivering such energy to the blood contact device stagnation points, initiation of thrombosis formation is prevented, thus preventing the accumulation of thrombosis to a dangerous risk level for stroke, pulmonary embolism, and/or other blood clot induced ailments. This device may be used to prevent and/or treat blood clot, plaque, and/or calcification formation on any blood contact surfaces including living surfaces such as heart valves.

A geared continuously variable transmission (GCVT) is provided. The GCVT includes a first set of solar gears having a first solar gear and first plurality of connection components. Power enters the GCVT through the first set of solar gears. The GCVT includes a second set of solar gears having a second solar gear and second plurality of connection components. Power exits the GCVT through the second set of solar gears. Power is transmitted from the first set of solar gears to the second set of solar gears via the first plurality of connection components and the second plurality of connection components. The GCVT includes a hydraulic pump and a hydraulic motor connecting first component from the first plurality of connection components to second component from the second plurality of connection components and providing constant rotation ratio between the first component and the second component.

The invention pertains to methods of treating alloys, particularly, biodegradable alloys containing Mg, Zn or Fe. The alloys can be treated with at least one of the following procedures: mechanical polishing, anodization, and polymer coating. Advantageously, methods provided herein enhance the anti-thrombogenicity of the alloy surface. Such materials can be used for preparing biomedical devices, such as endovascular implants, vascular implants, drug-eluting stents, orthopedic prostheses, or implantable chips. Methods of treating a subject by implanting the biomedical devices into the subject are also provided.

Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve coating the substrate to conceal or reduce flaws on or in the surface of the medical device or other article substrate, and thereafter forming a grafted polymer layer on the treated substrate surface.