Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.

Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.

A medical device substrate with a coating including a functional layer located on the substrate, with the functional layer including at least one sugar alcohol and being bonded to the substrate directly or indirectly via a functionalization of the sugar alcohol. Alternatively, the functional layer may also include other saccharides, in which case it is essential that polymerization of the saccharides takes place only upon bonding to the substrate. The inventive medical device exhibits reduced platelet adhesion and aggregation.

A medical device substrate with a coating including a functional layer located on the substrate, with the functional layer including at least one sugar alcohol and being bonded to the substrate directly or indirectly via a functionalization of the sugar alcohol. Alternatively, the functional layer may also include other saccharides, in which case it is essential that polymerization of the saccharides takes place only upon bonding to the substrate. The inventive medical device exhibits reduced platelet adhesion and aggregation.

A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.

Disclosed is an extracorporeal blood circulation device including a blood circulation circuit including a blood extraction line and a return line, a blood circulator in the circulation circuit and a control unit including a calculator arranged determining at least one parameter, recording it in a memory, and then comparing the standard value of the parameter with the recorded value. The device also includes a source of solution for liquefying blood clots, a device injecting and conveying the liquefaction solution in the circulation circuit, the control unit including a driver for the injector of the liquefaction solution. The control unit is arranged to actuate the driver when the value is exceeded, meaning that at least one clot has formed, the driver being arranged so that the liquefaction solution is present in the circulation circuit in an amount and for a time determined to be sufficient for liquefying the clot formed.

Disclosed is an extracorporeal blood circulation device including a blood circulation circuit including a blood extraction line and a return line, a blood circulator in the circulation circuit and a control unit including a calculator arranged determining at least one parameter, recording it in a memory, and then comparing the standard value of the parameter with the recorded value. The device also includes a source of solution for liquefying blood clots, a device injecting and conveying the liquefaction solution in the circulation circuit, the control unit including a driver for the injector of the liquefaction solution. The control unit is arranged to actuate the driver when the value is exceeded, meaning that at least one clot has formed, the driver being arranged so that the liquefaction solution is present in the circulation circuit in an amount and for a time determined to be sufficient for liquefying the clot formed.

There is provided herein a method of coating a polyurethane surface of an insertable medical device, the method comprising obtaining an insertable medical device or a part thereof comprising a polyurethane surface; performing a direct thiolization of the polyurethane surface to produce thiolated polyurethane surface comprising free thiol groups, the direct thiolization comprises a direct reaction between a secondary amine of the polyurethane surface and ethylene sulphide (ES) to form a covalent bond between the amine and the free thiol group; and reacting the thiolated polyurethane surface with a therapeutic/antithrombogenic compound having a vinyl/methacrylate functional group through thiol-ene click reaction, to produce an insertable medical device coated with a therapeutic/antithrombogenic and abrasion (delamination)-resistant coating.

The present invention discloses a compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications. In the present invention, the combination of curcumin and heparin can enhance the anticoagulation functions of heparin coating, and further enhance the stability using the properties of PLA-PEG-PLA drug-loaded sustained-release microspheres, achieving the functions of anti-tissue proliferation and anti-inflammatory reactions that cannot be achieved by coatings alone such as heparin or protein, which is very important for implanted devices such as artificial blood vessels, vascular stents and vascular patches to reduce thrombosis in the human body, lower postoperative complications and improve product lifespan.

The present invention discloses a compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications. In the present invention, the combination of curcumin and heparin can enhance the anticoagulation functions of heparin coating, and further enhance the stability using the properties of PLA-PEG-PLA drug-loaded sustained-release microspheres, achieving the functions of anti-tissue proliferation and anti-inflammatory reactions that cannot be achieved by coatings alone such as heparin or protein, which is very important for implanted devices such as artificial blood vessels, vascular stents and vascular patches to reduce thrombosis in the human body, lower postoperative complications and improve product lifespan.