The present invention relates to a method for grafting a surface of a medical device by using quaternized trimethylamine. A catheter onto which quaternized trimethylamine has been grafted allows for the reduction of thrombus production. Therefore, the catheter having quaternized trimethylamine grafted thereto exhibits the effect of repressing thrombus production and enhancing the function of inhibiting blood adsorption and blood cell adsorption.

The present invention relates to a method for grafting a surface of a medical device by using quaternized trimethylamine. A catheter onto which quaternized trimethylamine has been grafted allows for the reduction of thrombus production. Therefore, the catheter having quaternized trimethylamine grafted thereto exhibits the effect of repressing thrombus production and enhancing the function of inhibiting blood adsorption and blood cell adsorption.

A liquid excipient is added to a lock solution formulation containing a lower alcohol and an anti-coagulant, antibiotic, and/or anti-microbial, such as the ethanol and tri-sodium citrate lock solution formulation, to prevent citrate from crystallizing in catheters made from silicone. The locking solution could include a liquid excipient, such as glycerol, polysorbate-20, or polyethylene glycol (PEG)-400, along with a lower alcohol, such as ethanol, and an anti-coagulant, such as tri-sodium citrate, antibiotic, and/or anti-microbial.

A liquid excipient is added to a lock solution formulation containing a lower alcohol and an anti-coagulant, antibiotic, and/or anti-microbial, such as the ethanol and tri-sodium citrate lock solution formulation, to prevent citrate from crystallizing in catheters made from silicone. The locking solution could include a liquid excipient, such as glycerol, polysorbate-20, or polyethylene glycol (PEG)-400, along with a lower alcohol, such as ethanol, and an anti-coagulant, such as tri-sodium citrate, antibiotic, and/or anti-microbial.

The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.

The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.

The special infusion pump for stem cells includes a liquor storage device and an infusion pipe. The inner wall of the liquor storage sac and the infusion pipe is provided with a layer of anionic protective film, to prevent stem cells in physic liquor from adhering to the inner wall of the liquor storage sac and the infusion pipe using mutual repulsion between anions. The infusion method includes: checking an infusion pump for integrity; closing a liquor stop clamp, injecting a mixed liquor of stem cells and medicine; covering a protective cap, opening the liquor stop clamp, closing the liquor stop clamp for use; connecting an external cone joint with a venous cannula, and then opening the liquor stop clamp; steadily placing the liquor storage sac on a horizontal plane using an auxiliary placing device; and after infusion ends, closing the liquor stop clamp, and disconnecting the external cone joint.

The special infusion pump for stem cells includes a liquor storage device and an infusion pipe. The inner wall of the liquor storage sac and the infusion pipe is provided with a layer of anionic protective film, to prevent stem cells in physic liquor from adhering to the inner wall of the liquor storage sac and the infusion pipe using mutual repulsion between anions. The infusion method includes: checking an infusion pump for integrity; closing a liquor stop clamp, injecting a mixed liquor of stem cells and medicine; covering a protective cap, opening the liquor stop clamp, closing the liquor stop clamp for use; connecting an external cone joint with a venous cannula, and then opening the liquor stop clamp; steadily placing the liquor storage sac on a horizontal plane using an auxiliary placing device; and after infusion ends, closing the liquor stop clamp, and disconnecting the external cone joint.

Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.

Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.