A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.

A multi-layer tubular woven construct is useful as a hose that transports a fluid or a powder or protects linear bodies such as wires, cables and conduits, as a tubular filter, or as a base material of a vascular prosthesis. In particular, a tubular woven construct in a tubular configuration woven by interlacing warp and weft yarns contains at least in part an elastic fiber yarn having a filament fineness of 1.0 dtex or more, the weft yarn containing at least in part a microfiber yarn having a filament fineness of less than 1.0 dtex.

A multi-layer tubular woven construct is useful as a hose that transports a fluid or a powder or protects linear bodies such as wires, cables and conduits, as a tubular filter, or as a base material of a vascular prosthesis. In particular, a tubular woven construct in a tubular configuration woven by interlacing warp and weft yarns contains at least in part an elastic fiber yarn having a filament fineness of 1.0 dtex or more, the weft yarn containing at least in part a microfiber yarn having a filament fineness of less than 1.0 dtex.

The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). Slippery liquid-infused porous surfaces outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5?), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressures (up to at least 690 atm). Some exemplary application where slippery liquid-infused porous surfaces will be useful include energy-efficient fluid handling and transportation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating in extreme environments.

The disclosure relates to a medical material including a copolymer having a repeating unit (A) represented by the following formula (1): ##STR00001## wherein R.sup.11 is a hydrogen atom or a methyl group, Z is an oxygen atom or NH, R.sup.12 is a C.sub.1-6 alkylene group, R.sup.13 and R.sup.14 are each independently a C.sub.1-4 alkyl group, and R.sup.15 is a C.sub.1-6 alkylene group, and a repeating unit (B) represented by the following formula (2): ##STR00002## wherein R.sup.21 is a hydrogen atom or a methyl group, R.sup.22 is a C.sub.1-6 alkylene group, and R.sup.23 is a C.sub.1-4 alkyl group. The repeating unit (A) is contained in a proportion of 0.6 to 7 mol % based on all the structural units of the copolymer. The disclosure makes it possible to provide a medical material and a medical device, which exhibit excellent antithrombogenicity even when used under severe conditions prone to thrombus formation.

An artificial blood vessel includes a tubular woven fabric composed of a multifilament yarn A including a first polyester and a multifilament yarn B including a second polyester, and has an inner diameter of 8 mm or less and a layer thickness of 50 ?m or more and 250 ?m or less, wherein the multifilament yarn A has a single fiber fineness of 1.0 dtex or more and a total fineness of 33 dtex or less, the multifilament yarn B has a single fiber fineness of 0.08 dtex or less and a total fineness of 66 dtex or less, and the multifilament yarn B forms loops on an inner wall surface of the tubular woven fabric.

A coating composition comprises an aqueous solution comprising at least one vinyl carboxylic acid monomer and at least one neutral monomer, wherein the at least one neutral monomer has a glass transition temperature of less than about 100 C. in homopolymeric form. A device comprises a protonated polyacrylate coating, wherein the device is inherently antimicrobial, anti-thrombogenic, flexible, and/or sheds few to no particulates.

The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5?), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressure (up to at least 690 atm). Some exemplary application where SLIPS will be useful include energy-efficient fluid handling and transportation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating in extreme environments.

A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.