The present disclosure relates to anti-fouling and/or anti-thrombotic medical devices, methods for reducing fouling and/or thrombosis associated with medical devices, and methods for coating substrates to reduce fouling and/or thrombosis. Certain embodiments of the present disclosure provide an anti-fouling and/or anti-thrombotic medical device comprising a metallic substrate comprising a hyperbranched polyglycerol coating.

The present disclosure relates to anti-fouling and/or anti-thrombotic medical devices, methods for reducing fouling and/or thrombosis associated with medical devices, and methods for coating substrates to reduce fouling and/or thrombosis. Certain embodiments of the present disclosure provide an anti-fouling and/or anti-thrombotic medical device comprising a metallic substrate comprising a hyperbranched polyglycerol coating.

A copolymer is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof. The copolymer includes monomer unit A, monomer unit B, and monomer unit C, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.

A copolymer is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof. The copolymer includes monomer unit A, monomer unit B, and monomer unit C, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Disclosed are an implantable medical device, a preparation method thereof and an implantable medical device preform for the preparation of the implantable medical device. The implantable medical device comprises a metal basal body (21) and a polymer film layer (22) covering the surface of the metal basal body (21) and preventing endothelium growth and covering, and also comprises a transitional body (23), which is located between the metal basal body (21) and the polymer film layer (22) and covers at least part of the surface of the metal basal body (21), wherein the transitional body (23) is connected to the polymer film layer (22) and the metal basal body (21). By arranging the transitional body (23) to be connected to the polymer film layer (22) and the metal basal body (21), the polymer film layer (22) will not easily fall off when being implanted into a human body.

A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30 and less than 70, and the glass transition temperature of the copolymer exists at only one point in the range from 45 C. to less than 90 C.

A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30 and less than 70, and the glass transition temperature of the copolymer exists at only one point in the range from 45 C. to less than 90 C.

A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.