Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.

In one aspect, a composition for sustained release of oxygen to a tissue is disclosed that includes at least one core-shell oxygen release microsphere (ORM), wherein the core includes a water-soluble polymer-reactive oxygen species (ROS) complex and the shell includes a biodegradable polymer conjugated to a ROS-scavenging enzyme. In some aspects, the reactive oxygen species includes hydrogen peroxide (H.sub.2O.sub.2), the ROS-scavenging enzyme includes catalase, the water-soluble polymer includes polyvinylpyrrolidone (PVP), and the biodegradable polymer includes poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-co-acrylate-oligolactide-co-Nacryloxysuccinimide)[poly(NIPAAm-co-HEMA-co-AOLA-co-NAS)].

Certain embodiments are directed to methods and compositions for inhibiting, stabilizing or preventing fungal infections by yeast on a surface using an agent comprising one or more types of quantum dots sufficient to regulate the growth of fungal cells or biofilms thereof.

Methods for improving the antibacterial and/or bone-forming characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant may comprise a composite of a silicon nitride ceramic powder dispersed within a poly-ether-ether-ketone (PEEK) or a poly-ether-ketone-ketone (PEKK) substrate material. In some implementations, the biomedical implant may be 3D printed.

This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair.

Disclosed herein is a plasma treatment method comprising: providing a plasma source and a screen comprising a hydrogel and positioning the screen between the plasma source and a surface of a target to be treated with the plasma such that substantially all of the plasma from the plasma source passes through the screen prior to contacting the surface of the target and the screen reduces the concentration of one or more species from the plasma; and/or contacting a surface of a target to be treated with the gel composition comprising a gel forming material and a liquid phase comprising plasma activated liquid.

An entirely or partially implantable medical product with a negatively charged surface for repulsing bacteria has a superficially bonded substance with a permanently negative excess charge, which substance is inert against cells of the human body and the bacteria contained therein.

A dressing includes an application site covering and an oxygen scavenger provided with or positioned with respect to the application site covering so as to remove oxygen from a volume beneath the application site covering and around an application site covered by the application site covering. The application site covering and the oxygen scavenger are configured to maintain gas pressure beneath the application site covering around the application site that is above a therapeutic negative pressure while the oxygen scavenger is consuming oxygen beneath the application site covering.

The disclosed technology relates to a method of immobilising a protein on a substrate. The disclosed technology further relates to the substrate comprising the immobilised protein, the use of the substrate in a wound dressing, and the use of the wound dressing in a method of treating a wound.

A method of treating a topical ailments can include identifying an ailment, procuring a therapeutic composition, and administering the therapeutic composition to a subject. More specifically, the ailment can be associated with a topical region of a subject. The therapeutic composition can be sterilized and include a sodium carbonate mineral and a carboxylic acid. The therapeutic composition can be administered to the topical region of the subject.